Immunological diagnosis of tuberculosis (TB) is based on the immune responses against Mycobacterium tuberculosis (MTB). Immunological diagnosis can detect both active and latent TB, and can detect not only pulmonary TB but also extra-pulmonary TB. Compared to conventional diagnosis, immunological diagnostic tests have eminent advantages. On the other hand, there are still some limitations. As i...

The induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells. Defects in information transfer may result in the development of diseases, e.g. immunodeficiencies and autoimmunity. A distinct 3-dimensional supramolecular structure at the T cell/APC interface has been suggested to be invo...

Atopic dermatitis (AD) is a pruritic, relapsing, chronic disease that arises most commonly during infancy, childhood, or adolescence. It is clear that genetic factors are important in AD, a family history of AD, allergic rhinitis, and/or asthma and other “Atopic” phenomena being common in patient with AD. The two main pathogenetic characteristic of AD are: I) IgE-mediated antigen dependent “Spe...

manufacturing new hepatitis b virus vaccines, specifically by the use of nanoparticles, is of high global interest. in this paper, a new biocompatible and biodegradable structure of nano-sized hepatitis b virus’ surface antigen (hbsag) was generated by conjugation with dendrimers, a low cost biodegradable and biocompatible polymer. the physicochemical properties of the conjugate were characteri...

Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first validate an experimental immunological simulator, developed by the authors, by simulating several theories of immunological memory with known results. We then ...

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