Pairs of rats were immunized with keyhole limpet hemocyanin (KLH) and simultaneously labeled with thymidine-methyl-(3)H or 5-iodo-2'-deoxyuridine-(125)I. From 10-50 days later, their lymphoid organs were examined 3 days after anamnestic stimulation with KLH or after primary injection of BGG. Light and electron microscopic study of the labeled cells revealed that immunologic memory resided in th...

7 5 jci.org Volume 125 Number 1 January 2015 Introduction The term autophagy in its broadest sense refers to a set of diverse processes that deliver cytoplasmic constituents to lysosomes for degradation. In this Review, we focus only on the sensu stricto autophagy as a well-delineated pathway controlled by autophagyrelated gene–encoded (ATG-encoded) factors (1). Since general roles of autophagy...

The detection of an insulin antagonist in the serum of insulin resistant subjects has been attempted on a number of occasions. In certain instances, the excessive quantities of insulin used in the neutralization experiments in animals may explain the failure to obtain evidence of an insulin antagonist. In the few successful experiments which have been done, little information of a quantitative ...

UV radiation targets the skin and is a primary cause of skin cancer (both melanoma and nonmelanoma skin cancer). Exposure to UV radiation also suppresses the immune response, and UV-induced immune suppression is a major risk factor for skin cancer induction. The efforts of dermatologists and cancer biologists to understand how UV radiation exposure suppresses the immune response and contributes...

Thrombotic thrombocytopenic purpura endothelium and in thrombi in small (UP) is a disorder of unknown etiblood vessels in multiple organs. ology. An immunologic basis has been These findings suggest an active imsuggested, although proof is lacking. munologic process in this case. While The immunologic, hematologic, and UP is probably of diverse etiology, autopsy findings in a case of TTP occonf...

It is generally accepted that the immunologic mechanisms of the neonatal animal are poorly developed and in some instances virtually non-existent. This immunologic inadequacy early in life has been related both to the limited ability of the neonatal animal to synthesize gamma globulin and to the immunologic inexperience of the organism. However, it has not been determined whether the underlying...