The development of techniques for electron microscopic studies of biological specimens has made it possible to visualize fine structural details of intact cells in ultrathin sections. The high magnification power of electron microscopes, along with refined techniques for biological specimen preparation, has enabled a wealth of informations with respect to normal and pathological fine structure ...

The construction of artificial systems by drawing inspiration from natural systems is not a new idea. The Artificial Neural Network (ANN) and Genetic Algorithms (GAs) are good examples of successful applications of the biological metaphor to the solution of computational problems. The study of artificial immune systems is a relatively new field that tries to exploit the mechanisms of the natura...

Cutaneous lymphomas are a heterogeneous group of lymphoproliferative disorders. Most of the cutaneous lymphomas present a rather good prognosis because they disseminate to internal organs late in the disease process, if at all. Since radiotherapy and intensive chemotherapy have limited efficacy, immunological interventions are regularly used in this disease group. These interventions include un...

Immuno-PCR (IPCR) is a powerful detection technology in immunological study and clinical diagnosis due to its ultrasensitivity. Here we introduce a new strategy termed phage display mediated immuno-PCR (PD-IPCR). Instead of utilization of monoclonal antibody (mAb) and chemically bond DNA that required in the conventional IPCR, a recombinant phage particle is applied as a ready reagent for IPCR ...

Diabetes Mellitus (DM) is a group of metabolic disorders with relative or absolute insufficiency insulin secretion and/or concomitant resistance to the action on target tissues. Aim: evaluate effect STZ-induced-DM dental pulp albino rats histologically and ultra-structurally, its pulpal TB Sub-group B1 B2 where animals were sacrificed 2 4 weeks after establishment DM respectively. permanent mol...

Fertility and immunity are concurrently upregulated in Drosophila melanogaster females after normal mating, potentially requiring physiological trade-offs. Using a novel bacterial introduction method, I observed female copulatory Serratia marcescens receipt and infection. Immuno-competent females surviving copulatory S. marcescens exposure had significantly reduced progeny production during the...

This paper describes a microfluidic immunoassay device with integrated preconcentration system, enabling the detection of various analytes (proteins) at low target concentrations with faster binding kinetics. It not only complements recent advances of novel immuno-biosensors, but also can be used to further enhance the most novel and advanced immuno-biosensor systems developed. The work has dem...

Schimke immuno-osseous dysplasia is an autosomal recessive multisystem disorder caused by defects in SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1 gene (SMARCAL1). SMARCAL1 product is a helicase that has role in selective cellular proliferation. The disorder is characterized by spondyloepiphyseal dysplasia with short stature, nephropathy, T cell ...

In this study, we present a new technique called correlative atomic force and transmission electron microscopy (correlative AFM/TEM) in which a targeted region of a sample can be observed under AFM and TEM. The ultimate goal of developing this new technique is to provide a technical platform to expand the fields of AFM application to complex biological systems such as cell extracts. Recent adva...