The immune status of an individual is made up of the absolute number (cells/μl) and relative ratios of each category of immune cells. To determine the extent of similarity of the immune status between individuals across malignancies, we described the immune status using quantitative whole blood flow cytometry of ten immune markers and generated immune phenotypes from 40 healthy volunteers and 1...

allergen-specific immunotherapy (ait) has been recently considered as an alternative approach to ameliorate the symptoms of allergen exposure and improvement the patients’ quality of life. dendritic cells (dc) in the forms of tolerogenic or th1-induced cells have been investigated in several studies as one of the promising approaches of ait in allergic diseases. the aim of this study was to eva...

Abstract Recent advances in single cell expression technology have allowed us to appreciate the complexity tumoral heterogeneity of solid tumors such as glioblastoma (GBM), which remains uniformly fatal despite aggressive therapies. Currently, there is no knowledge about identities and functional characteristics different populations. To this end, we created a 28-marker mass cytometry panel com...

PURPOSE OF REVIEW The pathogenesis of HIV infection is highly complex and involves numerous actors of the immune system. On the one hand, our immunity has a predominant role in limiting HIV replication and the depletion of its targets, but on the other hand, the persistent infection established by the virus is associated with chronic immune activation and inflammation, potentially resulting in ...

The mechanisms underlying tick resistance within and between cattle breeds have been studied for decades. Several previous papers on bovine immune parameters contributing to tick resistance discussed findings across DNA, RNA, protein, cellular, and tissue levels. However, the differences between bovine host species, tick species and the experimental layouts were not always taken into account. T...

BACKGROUND Aging is associated with immune dysfunction and the related development of conditions with an inflammatory pathogenesis. Some of these immune changes are also observed in HIV infection, but the interaction between immune changes with aging and HIV infection are unknown. Whilst sex differences in innate immunity are recognized, little research into innate immune aging has been perform...

The presence and composition of lymphocytes characterizing an immune response has been connected to prognosis in advanced ovarian cancer. Our aim is to establish novel associations between prognosis and the expression of immune-related genes through a focused screen utilizing publicly available high-throughput assays. We consider transcriptome profiles from n=1137 advanced ovarian cancer patien...

Immune defenses are expected to be crucial for survival under the considerable parasite pressures experienced by wild animals. However, our understanding of the association between immunity and fitness in nature remains limited due to both the complexity of the vertebrate immune system and the often-limited availability of immune reagents in nonmodel organisms. Here, we use methods and reagents...