Total serum hemolytic complement activity is consistently reduced in animals undergoing accelerated "serum sickness". The time of maximum reduction in complement titer invariably coincides with the time of complete antigen disappearance. This temporal relationship supports the belief that the reduction in complement titer is brought about by in vivo antigen-antibody combination. The intravenous...

Drug-induced immune hemolytic anemia (DIIHA) is rare; it can be mild or associated with acute severe hemolytic anemia (HA) and death. About 125 drugs have been implicated as the cause. The HA can be caused by drug-independent antibodies that are indistinguishable, in vitro and in vivo, from autoantibodies causing idiopathic warm type autoimmune hemolytic anemia (AIHA). More commonly, the antibo...

Objective(s):Gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. In this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo. Materials and Methods: Three doses of gemifloxacin 25 mg/kg, 50 mg/kg and 75 mg/kg were used intraperitoneally (IP) for the evaluation ...

Severe thrombocytopenia is a cause of morbidity and mortality for patients with COVID-19 infection. The common causes in these are; sepsis, drug-associated, disseminated intravascular coagulation (DIC), heparin-associated (HIT), microangiopathic hemolytic anemia (MAHA). Recently, cases infection-associated Immune thrombocytopenic purpura (ITP) have been reported the literature. In our study, we...

Abstract   Introduction: Hemoglobin Constant Spring (Hb CS),  a abnormal Hb characterized by elongated α-globin chain resulting from mutations of the termination codon in the α2 - globin gene , is the most common nondelitional  α-thalassemic mutation and is an important cause of HbH like disease in Southeast Asia. Case Report: A 9- years-old female with immune hemolytic anemia and splenomegally...

1. The water-insoluble globulin with which hemolysin is associated, may be separated from immune serum or plasma by dilution and simple dialysis at optimal pH. 2. This optimum in plasma is influenced by the presence of the fibrinogen. 3. Fibrinogen carries no immune body, or only an insignificant amount; when present in immune body solutions in other form than fibrin gel, it depresses the hemol...

I T IS NOW evident that the syndrome of acquired hemolytic anemia represents a distinct entity which is separate in pathogenesis and course from the commonly described familial hemolytic jaundice. This distinction, which was recognized by the writers of the early part of the century, was lost sight of by many more recent observers, who suggested that acquired hemolytic anemia was simply a sudde...