The title compound, C9H8N2O3, was prepared by reaction of phenol, glyoxylic acid and urea in water. The imidazolidine ring adopts an almost planar conformation (r.m.s. deviation = 0.012 Å) and is twisted by 89.3 (1)° relative to the benzene ring. In the crystal, mol-ecules are linked by N-H⋯O and O-H⋯O hydrogen bonds into a three-dimensional framework.

In the title binuclear compound, [Zn(2)(C(27)H(27)N(4)O(3))(C(2)H(3)O(2))]·2CH(3)CH(2)OH·2H(2)O, both Zn cations adopt distorted ZnO(3)N(2) trigonal-bipyramidal geometries with one N atom in a axial site and one N atom in an equatorial site, arising from coordination by the N,N,N,N,O,O,O-hepta-dentate ligand and a bridging acetate ion. In the crystal, inter-molecular O-H⋯O hydrogen bonds link t...

Derivatives of thiazolidinone ring systems are known to act as anti-HIV infections , analgesic, anti-bacterial, anti-convulsant, anti parasitic, potential anti-inflammatory and herbicidal agents. Due biological activities of thiazolidinones ring, several methods for their synthesis have been illustrated in literature. Imidazolidine-2-thiones were synthesized by the oxidative cyclization of 1-be...

A simple, fast and cost-effective three-step synthesis of 1-methyl-8-phenyl-1,3-diazaspiro[4.5]decane-2,4-dione has been developed. The reactions described herein proceed readily, with high yields no further purification. Therefore, the proposed method, an overall yield 60%, offers a facile pathway to N-1 monosubstituted spiro carbocyclic imidazolidine-2,4-diones (hydantoins), which constitute ...

In the title compound, C(14)H(14)N(4), the imidazolidine moiety is nearly planar, having an N-C-N-C torsion angle of 4.43 (3)°. The crystal structure is characterized by classical N-H⋯N hydrogen bonds, which form inversion dimers.

In thymidylate synthase (TS), the invariant residue Asp-221 provides the only side chain that hydrogen bonds to the pterin ring of the cofactor, 5,10-methylene-5,6,7,8-tetrahydrofolate. All mutants of D221 except cysteine abolish activity. We have determined the crystal structures of two ternary complexes of the Escherichia coli mutant D221N. In a complex with dUMP and the antifolate 10-proparg...