نتایج جستجو برای: imidazoles multicomponent nmr

تعداد نتایج: 72088  

Journal: :Molbank 2022

An efficient telescoped method for synthesis of 3-phenyl-10-(2,3,4-trimethoxyphenyl)-9,10-dihydro-4H,8H-pyrano[2,3-f]chromene-4,8-dione was elaborated. The presented protocol includes the one-pot multicomponent reaction 7-hydroxy-3-phenyl-4H-chromen-4-one, 2,3,4-trimethoxybenzaldehyde and Meldrum’s acid. Advantages this are application readily available starting reagents, atom economy easy proc...

Journal: Nanochemistry Research 2019

Nano-Fe3O4 attached to Crosslinked sulfonated polyacrylamide (Cross-PAA-SO3H) as a superior catalyst has been utilized for the preparation of 3-alkyl-4-phenyl-1,3-thiazole-2(3H)-thione derivatives through a three-component reactions of phenacyl bromide or 4-methoxyphenacyl bromide, carbon disulfide and primary amine. The best results were gained in ethanol and we found that the reaction gave co...

Journal: :Journal of the American Chemical Society 2001
X Sun M D Winemiller B Xiang D B Collum

Low-temperature (6)Li, (13)C, and (15)N NMR spectroscopies reveal that mixtures of n-BuLi and (1R,2S)-R'(2)NCH(R)CH(Ph)OLi (ROLi; R = Ph or Me; R'(2)N = pyrrolidino or Me(2)N) in THF/pentane afford a (n-BuLi)(3)(ROLi) (3:1) mixed tetramer and a C(2)-symmetric (n-BuLi)(2)(ROLi)(2) (2:2) mixed tetramer depending on the proportions of the reactants. The corresponding (n-BuLi)(ROLi)(3) (1:3) mixed ...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2002
Sanna Kaivosaari Jarmo S Salonen Jyrki Taskinen

N-Glucuronidation in vitro of six 4-arylalkyl-1H-imidazoles (both enantiomers of medetomidine, detomidine, atipamezole, and two other closely related compounds) by rat, dog, and human liver microsomes and by four expressed human UDP-glucuronosyltransferase isoenzymes was studied. Human liver microsomes formed N-glucuronides of 4-arylalkyl-1H-imidazoles with high activity, with apparent V(max) v...

2012
Arthur Kammeyer Charlotte P. Peters Sybren L. Meijer Anje A. te Velde

Urocanic acid (UCA) derivatives were tested for their anti-inflammatory activity in inflammatory bowel disease (IBD) in two models: ex vivo and an experimental mouse model. Ex vivo: inflamed colonic tissue was incubated in culture medium with or without the UCA derivatives. Biopsies, incubated with UCA derivatives, produced lower levels of proinflammatory cytokines IL-6 and IL-8 as compared to ...

Journal: :Acta Chemica Scandinavica 1973

Journal: :Molbank 2022

A simple and efficient protocol for the synthesis of previously unknown 2-(2-(4-methoxyphenyl)furo[3,2-h]quinolin-3-yl)acetic acid was elaborated. The suggested method is based on telescoped multicomponent reaction 8-hydroxyquinoline, 4-methylglyoxal, Meldrum’s acid. studied process includes initial interaction starting compounds in MeCN followed by intramolecular cyclization to target product ...

2009
James N. Iley Maria Sanchis-Amat Xiaohui Zhang Mark R.J. Elsegood Raymond C. F. Jones Mark R. J. Elsegood

A catalytic method involving carbenoid insertion onto dihydroimidazoles is reported for the generation of dihydroimidazolium ylides, and their subsequent diastereoselective cycloaddition to form pyrrolo[1,2-a]imidazoles © 2009 Elsevier Science. All rights reserved ———

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