Synthetic studies of C4-linked imidazole C-nucleosides toward biofunctional molecules are described, in which the following items are covered. 1) Stereoselective synthesis of imidazole C- and pyrazole C-nucleosides via diazafulvene intermediates. 2) Synthesis of tetrahydrofuranylimidazoles using a PhSe group efficiently and its application to the new human histamine H(3) receptor (hH(3)R) agoni...

The asymmetric unit of the title compound, [Co(C(3)H(4)N(2))(6)][Co(C(3)H(4)N(2))(3)(H(2)O)(3)](C(12)H(6)O(4))(2), contains two halves of crystallographically independent Co(II) complex cations, each assuming a distorted octa-hedral geometry, and one uncoordinated naphthalene-1,4-dicarboxyl-ate dianion. One Co(II) cation is located on an inversion center and is coordinated by six imidazole mol-...

15N nuclear spins of imidazole-15N2 were hyperpolarized using NMR signal amplification by reversible exchange in shield enables alignment transfer to heteronuclei (SABRE-SHEATH). A 15N NMR signal enhancement of ∼2000-fold at 9.4 T is reported using parahydrogen gas (∼50% para-) and ∼0.1 M imidazole-15N2 in methanol:aqueous buffer (∼1:1). Proton binding to a 15N site of imidazole occurs at physi...

The asymmetric unit of the crystal structure of the title compound, [Cd(2)Cl(4)(C(5)H(8)N(2))(3)](n), contains two Cd(II) cations, three 1-ethyl-1H-imidazole ligands, and four Cl(-) anions. The two Cd(II) atoms have quite different coordination environments: one is octa-hedrally coordinated by four Cl atoms and two N atoms from two 1-ethyl-1H-imidazole ligands, and the second is in a severely d...

We performed first principles molecular dynamics simulations to elucidate the mechanism and role of 1,2,3-triazole in proton transport while it is mixed with phosphoric acid (PA) and a phosphoric acid imidazole mixture. PA doped imidazole based polymer acts as an efficient polyelectrolyte membrane for fuel cells. The conductivity of this membrane increases when triazole is added to the system. ...

The mononuclear title compound, [ZnCl2(C15H12N2)2], was synthesized by reaction of zinc chloride and 1-(biphenyl-4-yl)-1H-imidazole (bpi) under hydro-thermal conditions. The Zn(II) atom is tetra-hedrally coordinated by the free imidazole N atoms of two bpi ligands and by two Cl atoms. The bpi ligands are not planar, with dihedral angles of 37.52 (14) and 42.45 (14)° between the phenyl rings and...

Previous studies have shown that exposure to imidazole dissociates hemoglobin synthesis from other aspects of cell maturation in dimethylsulfoxide (DMSO)-treated mouse erythroleukemia (MEL) cells. In the present study, we have found that imidazole causes hyperpolarization of the mitochondrial membrane in MEL cells exposed to DMSO, in contrast to the depolarization observed with DMSO alone. Like...

The synthesis of imidazole styrylbenzamide, tert-butyl styrylimidazole, and tert-butyl styrylsulfonate derivatives is described. Evaluation of binding affinity and inhibitory activity against CYP24A1 identified the imidazole styrylbenzamides as potent inhibitors of CYP24A1, having selectivity with respect to CYP27B1 comparable with or greater than that of the standard ketoconazole. Further eval...

The crystal structure of di-μ(3)-chlorido-tetra-μ(2)-chlorido-dichloridoocta-(imidazole-κN)tetra-manganese(II) ethanol 1.234 solvate, [Mn(4)Cl(8)(C(3)H(4)N(2))(8)]·1.234C(2)H(5)O or [Mn(4)Cl(8)(Him)(8)]·1.234EtOH, where Him is imidazole (C(3)H(4)N(2)), is based upon two Mn(4)Cl(4) cubes which share one face, and which each lack one manganese vertex, giving a Mn(4)Cl(6) unit. This contains two d...

Syntheses of various classes of fused-imidazoles are reported. The key to their successful synthesis depends on the reaction of N-vinyl-1H-imidazole with the π-deficient compounds under basic conditions. Reaction of the target imidazole with 1,1,2,2-tetracyanoethylene and dimethyl acetylenedicarboxylate afforded pyrrolo[1,2-a]imidazoles. On the other site, reaction of the target imidazole with ...