Activation of autonomic neural pathways by chronic hypertensive stimuli plays a significant role in pathogenesis of hypertension. Here, we proposed that even a single acute hypertensive stimulus will activate neural and immune pathways that may be important in initiation of memory imprinting seen in chronic hypertension. We investigated the effects of acute angiotensin II (Ang II) administratio...

Background Psoriatic arthropathy (PsA) is a heterogeneous chronic entity with multiple clinical domains that evolves to irreversible damage both organic and psychological. Therapeutic recommendation guidelines advise differentiated therapies according the dominant domain (e.g., peripheral arthritis, dactylitis, enthesitis, spondylitis, cutaneous or nail psoriasis). Moderate-severe involvement r...

BACKGROUND Rheumatoid arthritis (RA) has been associated with an increased risk of infections, but the underlying pathways have not yet been identified. Toll-like receptors (TLR) probably play a role in synovial inflammation and may also contribute to the understanding of the role of infections in RA. OBJECTIVES To investigate if the synovial expression of TLR3 and TLR7 in RA correlates with ...

IL23/IL17 pathway plays an important role in the development of inflammatory bowel diseases (IBD). In general, the genes encoding the cytokines are genetically polymorphic and polymorphisms in genes IL23R and IL17 have been proved to be associated with its susceptibility to inflammatory diseases as well as cancer including colorectal cancer. Moreover, it has been shown that these interleukins a...

UNLABELLED The composition of the human intestinal microbiota is linked to health status. The aim was to analyze the microbiota of normal and colon cancer patients in order to establish cancer-related dysbiosis. PATIENTS AND METHODS Stool bacterial DNA was extracted prior to colonoscopy from 179 patients: 60 with colorectal cancer, and 119 with normal colonoscopy. Bacterial genes obtained by ...

PURPOSE Infusion of HER2-specific T cells, derived from vaccine-primed patients and expanded with IL2/IL12, has induced tumor regression in a minority of patients with metastatic treatment-refractory HER2(+) breast cancer. We questioned whether alteration of cytokine growth factors used to culture vaccine-primed T cells could improve antitumor activity. EXPERIMENTAL DESIGN Using the TgMMTV-ne...

BACKGROUND Vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) is widely used to reduce the risk of childhood tuberculosis and has been reported to have efficacy against two other mycobacterial diseases, leprosy and Buruli ulcer caused by M. ulcerans (Mu). Studies in experimental models have also shown some efficacy against infection caused by Mu. In mice, most studies use the C5...

The role of the interleukin (IL)23/IL17 axis in psoriasis is well-established and has led to development biologics targeting IL23 IL17A. Ustekinumab, targets IL12/23p40 shared subunit blocks IL23-receptor interactions, restricting activation Signal Transducer Activator Transcription 3 (STAT3) T cells, IL17A production. Secukinumab binding its receptor, preventing keratinocyte activation. Althou...

Biologics targeting specific cytokines and pathways have revolutionized the management of patients with chronic inflammatory diseases such as psoriasis. Although generally very safe, these treatments their limitations and, surprisingly, can aggravate pre-existing or induce novel diseases. Here, we present a cohort psoriasis developing new onset eczema during anti-IL17 treatment, an intriguing s...

Psoriasis affects 3% of the population worldwide, and there is no known cure. Psoriasis is associated with an increased risk of psoriatic arthritis, lymphomas, cardiovascular disease, and Crohn’s disease. Psoriasis treatments today include steroid and vitamin D3 cream, ultraviolet light, and immune systemsuppressing medications such as methotrexate. The T cells responsible for psoriasis are Th1...