Chronic hepatitis C (CHC) pathogenic mechanisms as well the participation of immune response in generation liver damage are still a topic interest. Here, we evaluated cell populations and cytokines peripheral blood (PB) to elucidate their role CHC pathogenesis. B, CTL, Th, Treg, Th1, Th17, NK localization frequency were on biopsies by immunohistochemistry, while frequency, differentiation, func...

Bachground: Endometriosis is a disease of female genital system, which is defined by the presence of ectopic endometrial tissue outside the uterine cavity. IL-8 is an autocrine growth factor in the endometrium that contributes to the pathogenesis of endometriosis. The aim of this study was to investigate the association between -251T/A polymorphism in the IL-8 gene and endometriosis risk in Ira...

Lung epithelial cells contribute to local inflammation by the production of pro-inflammatory mediators like interleukin (IL)-8 and IL-6. Although their production depends on gene transcription, previous studies showed that post-transcriptional mechanisms modulate IL-8 and IL-6 production. Human lung epithelial cells turn from normoresponsive into hyperresponsive IL-8- and IL-6-producing cells w...

The mechanism of hepatocellular liver damage after COVID-19 is a multifactorial process. most widely discussed causes are cytolytic due to the inflammatory response COVID-19, drug-induced hepatotoxicity and direct cytotoxic effect virus. There observations that SARSCoV-2 infection hepatitis B virus reactivation, but little has been described about interaction between C SARS-CoV-2. course corona...

Background: Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the white matter of the Central Nervous System (CNS). Proinflammatory cytokine network such as interleukin-6 (IL-6) has a role in the initiation of a destructive immune response in CNS and the progression of the disease. This study aimed to evaluate the comparative levels of IL-6 and IL-8 in MS patients and h...

Shiga toxins (Stxs) are bacterial virulence factors produced by Shigella dysenteriae serotype 1 and Escherichia coli strains. Stxs are critical factors for the development of diseases such as severe bloody diarrhea and hemolytic uremic syndrome. Additionally, Stxs trigger the secretion of pro- inflammatory cytokines and chemokines, particularly in monocytes or macrophages. The inflammatory cyto...