IGR J19140+0951 was discovered by INTEGRAL in 2003 in the 4-100 keV band. Observations with INTEGRAL and RXTE provide a tentative identification as a high-mass X-ray binary (HMXB) with a neutron star as accretor. However, an optical counterpart was thus far not established. Neither was the presence of a pulsar, which is commonly observed in HMXBs. We have observed IGR J19140+0951 with Chandra a...

Analysis of the immunoglobulin receptor (IGR) variable heavy- and light-chain sequences on 17 hepatitis C virus (HCV)-associated non-Hodgkin lymphomas (NHLs) (9 patients also had type II mixed cryoglobulinemia [MC] syndrome and 8 had NHL unrelated to MC) and analysis of intraclonal diversity on 8 of them suggest that such malignant lymphoproliferations derive from an antigen-driven pathologic p...

IGR J18214-1318, a Galactic source discovered by the International Gamma-Ray Astrophysics Laboratory, is a high-mass X-ray binary (HMXB) with a supergiant O-type stellar donor. We report on the XMM-Newton and NuSTAR observations that were undertaken to determine the nature of the compact object in this system. This source exhibits high levels of aperiodic variability, but no periodic pulsations...

AIMS Thyroid dysfunction is frequently observed in patients with type 2 diabetes mellitus (T2DM), but the underlying mechanism is still poorly understood. The present study aimed to investigate whether nesfatin-1 played a role in the thyroid dysfunction in patients with T2DM. METHODS 55 euthyroid patients were enrolled in this study including 30 patients with T2DM and 25 patients with impaire...

Context. IGR J09026−4812 was discovered by INTEGRAL in 2006 as a new hard X-ray source. Thereafter, an observation with Chandra pinpointed a single X-ray source within the ISGRI error circle, showing a hard spectrum, and improving its high-energy localisation to a subarcsecond accuracy. Thus, the X-ray source was associated to the infrared counterpart 2MASS J09023731−4813339 whose JHKS photomet...

While modern therapies for metastatic prostate cancer (PCa) have improved survival they are associated with an increasingly prevalent entity, aggressive variant PCa (AVPCa), lacking androgen receptor (AR) expression, enriched for cancer stem cells (CSCs), and evidencing epithelial-mesenchymal plasticity with a varying extent of neuroendocrine transdifferentiation. Parallel work revealed that en...

Background and Aims. Women with former gestational diabetes (fGDM) are characterized by impaired beta-cell function (BC). Incretin hormones contribute to insulin secretion after oral administration of glucose. We aimed to assess the possible role of incretins on altered insulin release in fGDM. Materials and Methods. We studied 104 fGDM women within 6 months after delivery and 35 healthy women ...

In this paper we present INTEGRAL observations of 7 AGNs: two newly discovered type 1 Seyferts, IGR J18027-1455 and IGR J21247+5058, and five well known Seyferts, NGC 6814 (type 1.5), Cyg A (Type 2), MCG-05-23-16 (type 2), ESO 103-G035 (type2) and GRS1734-292. For IGR J18027-1455 and IGR J21247+5058 only INTEGRAL/IBIS data were available, while broadband spectra are presented and discussed for ...

Abstract Relaxed clock models are fundamental in Bayesian dating, but a single distribution characterizing the variation is typically selected. Hence, I developed new reversible-jump Markov chain Monte Carlo (rjMCMC) algorithm for drawing posterior samples between independent lognormal (ILN) and gamma rates (IGR) models. The ability of rjMCMC to infer true model was verified through simulations...