نتایج جستجو برای: ifn β

تعداد نتایج: 211090  

2015
Tanel Mahlakõiv Pedro Hernandez Konrad Gronke Andreas Diefenbach Peter Staeheli

Epithelial cells are a major port of entry for many viruses, but the molecular networks which protect barrier surfaces against viral infections are incompletely understood. Viral infections induce simultaneous production of type I (IFN-α/β) and type III (IFN-λ) interferons. All nucleated cells are believed to respond to IFN-α/β, whereas IFN-λ responses are largely confined to epithelial cells. ...

Journal: :Journal of immunology 2015
Feng Ma Bing Li Su-yang Liu Shankar S Iyer Yongxin Yu Aiping Wu Genhong Cheng

Rapid and robust induction of type I IFN (IFN-I) is a critical event in host antiviral innate immune response. It has been well demonstrated that cyclic GMP-AMP (cGAMP) synthase (cGAS) plays an important role in sensing cytosolic DNA and triggering STING dependent signaling to induce IFN-I. However, it is largely unknown how cGAS itself is regulated during pathogen infection and IFN-I productio...

2016
Sojan Abraham Jang-Gi Choi Nora M. Ortega Junli Zhang Premlata Shankar N. Manjunath Swamy

Because endogenous interferon type I (IFN-I) produced by HIV-1 infection might complicate the analysis of therapeutically administered IFN-I, we tested different humanized mouse models for induction of IFN-I during HIV-1 infection. While HIV-1 induced high levels of IFN-α in BLT mice, IFN-I was undetectable following infection in the Hu-PBL mouse model, in which only T cells expand. We therefor...

2017
Vincenzo Dattola Lilla Bonanno Antonino Naro Antonino Chillura Anna Lisa Logiudice Edoardo Sessa Fausto Famà Angelo Quartarone Rocco Salvatore Calabrò Silvia Marino Margherita Russo

Interferon beta (IFN-β) therapy is one of the most commonly prescribed immunomodulatory therapies in relapsing-remitting multiple sclerosis (RRMS). A reversible cerebral vasoconstriction syndrome (RCVS), associated with IFN-β use, has been recently described. For this reason, we tested the effect of once a week intramuscular administration of IFN-β-1A on the function of cerebral vessels in a co...

Journal: :Journal of virology 2012
Carsten Kallfass Andreas Ackerman Stefan Lienenklaus Siegfried Weiss Bernd Heimrich Peter Staeheli

Beta interferon (IFN-β) is a major component of innate immunity in mammals, but information on the in vivo source of this cytokine after pathogen infection is still scarce. To identify the cell types responsible for IFN-β production during viral encephalitis, we used reporter mice that express firefly luciferase under the control of the IFN-β promoter and stained organ sections with luciferase-...

Journal: :Journal of virology 2012
Larissa B Thackray Erning Duan Helen M Lazear Amal Kambal Robert D Schreiber Michael S Diamond Herbert W Virgin

Human noroviruses (HuNoV) are the major cause of epidemic, nonbacterial gastroenteritis in the world. The short course of HuNoV-induced symptoms has implicated innate immunity in control of norovirus (NoV) infection. Studies using murine norovirus (MNV) confirm the importance of innate immune responses during NoV infection. Type I alpha and beta interferons (IFN-α/β) limit HuNoV replicon functi...

2004
L. C. Miller W. W. Laegreid J. L. Bono C. G. Chitko-McKown Roman L. Hruska

Infection by porcine reproductive and respiratory syndrome virus (PRRSV) results in a weak induction of the innate immune response. There are many genes that collectively comprise this response and the extent to which each gene responds to PRRSV infection is unclear and warrants further investigation. To this end, we have utilized real-time PCR using SYBR Green I dye-based detection to quantify...

2014
Éric Toussirot Matthieu Béreau Marie Bossert Imad Malkoun Anne Lohse

Interferon beta (IFN- β ) is the first line therapy of relapsing-remitting multiple sclerosis. IFN- β is a cytokine that can contribute to the development of systemic autoimmune disease including psoriasis. The development or the exacerbation of psoriasis during IFN- β treatment has been previously observed. We report the occurrence of arthritis and dactylitis in a multiple sclerosis patient wi...

2011
Yongjun Tian Wen-ling Chen Jing-hsiung James Ou

Interferons α and β (IFN-α/β) are type I interferons produced by the host to control microbial infections. However, the use of IFN-α to treat hepatitis B virus (HBV) patients generated sustained response to only a minority of patients. By using HBV transgenic mice as a model and by using hydrodynamic injection to introduce HBV DNA into the mouse liver, we studied the effect of IFN-α/β on HBV in...

Journal: :Science signaling 2012
Makoto Inoue Kristi L Williams Timothy Oliver Peter Vandenabeele Jayant V Rajan Edward A Miao Mari L Shinohara

Interferon-β (IFN-β) is widely used to treat multiple sclerosis (MS), and its efficacy was demonstrated in the setting of experimental autoimmune encephalomyelitis (EAE), an animal model of MS; however, IFN-β is not effective in treating all cases of MS. Here, we demonstrate that signaling by IFNAR (the shared receptor for IFN-α and IFN-β) on macrophages inhibits activation of Rac1 and the gene...

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