Background: Data shows vanadium protects pancreatic beta cells (BC) from diabetic animals. Whether this effect is direct or through the relief of glucose toxicity is not clear. This study evaluated the potential effect of oral vanadyl sulfate (vanadium) on glycemic status and pancreatic BC of normal and diabetic rats. Methods: Rats were divided into five groups of normal and diabetic. Diabetes ...

conclusions the results of this study show the factors related to the return-to-work after bc treatment in working women in mashhad city, iran. these predictors should be taken into account in order to improve the patient’s life quality. background most women are diagnosed with breast cancer (bc) when they are still at the appropriate age for employment. the increasing survival rates of patient...

A constrained version of the Big Bang-Big Crunch algorithm for the efficient solution of the optimal reservoir operation problems is proposed in this paper. Big Bang-Big Crunch (BB-BC) algorithm is a new meta-heuristic population-based algorithm that relies on one of the theories of the evolution of universe namely, the Big Bang and Big Crunch theory. An improved formulation of the algorithm na...

Long intergenic non-coding RNA (lincRNA) has been introduced as key regulators of diverse biological processes, including transcription, chromatin organization, cell growth and tumorigenesis. With regard to the potential role of lincRNAs in cancer development, one may postulate that differential expression of lincRNAs could be employed as a tool in cancer diagnosis, prognosis, and targeted ther...

miRNAs are small non-coding RNAs that inhibit gene expression by cleaving or hindering the translation of target mRNAs. In this study, we focused on miR-431, which mediated inhibition of cell viability by human interferon-β (HuIFN-β). We aimed to demonstrate an antineoplastic effect of HuIFN-β via miR-431 expression against medulloblastoma and glioblastoma, because HuIFN-β is frequently used in...

Introduction: Dietary acid load contributes to metabolic acidosis, closely linked to cancer development through inflammation and cell transformation. There is very limited epidemiologic evidence; linking diet-dependent acid load and cancer risk. Since there are few published studies specifically on urinary pH and bladder cancer (BC) risk, we sought to explore this association in the present stud...

Synapse loss is well regarded as the underlying cause for the progressive decline of memory function over the course of Alzheimer’s disease (AD) development. Recent observations suggest that the accumulation of the Wnt antagonist Dickkopf-1 (Dkk1) in the AD brain plays a critical role in triggering synaptic degeneration. Mechanistically, Dkk1 cooperates with Kremen1 (Krm1), its transmembrane re...

The development of ultrafine bainitic structure in AISI 431 stainless steel was the goal of this study. For this purpose, the AISI 431 specimens were austenitized at 1100 °C for 60 min followed by low-temperature austempering treatment at different temperatures and times. Austempered samples were characterized using field emission scanning electron microscopy (FESEM), X-ray diffraction (X...