AIM The aim of the study was to examine cross-sectional association between serum albumin and hyperuricemia (HU). MATERIALS AND METHODS HU defined as uric acid ? 420 umol/L for male population ? 357 umol/Lfor female population. We reviewed files 216 consecutive patients with idiopathic membranous nephropathy treated at our hospital 2010 2019. correlation levels clinical Idiopathic were assessed...

There has been a re-emergence of interest in adrenocorticotropic hormone (ACTH) in patients with resistant nephrotic syndrome. We describe a patient with severe nephrosis and advanced chronic kidney disease with idiopathic membranous nephropathy resistant to conventional immunosuppressive therapies that achieved lasting remission with ACTH therapy. We explore the literature showing the extra re...

To assess whether chlorambucil or cyclophosphamide may have a better therapeutic index in patients with idiopathic membranous nephropathy, we compared two regimens based on a 6-mo treatment, alternating every other month methylprednisolone with chlorambucil or methylprednisolone with cyclophosphamide. Patients with biopsy-proven membranous nephropathy and with a nephrotic syndrome were randomiz...

BACKGROUND H.P. Acthar(®) Gel is currently the only Food and Drug Administration therapy approved for the treatment of nephrotic syndrome. Active drug ingredients include structurally related melanocortin peptides that bind to cell surface G-protein-coupled receptors known as melanocortin receptors, which are expressed in glomerular podocytes. In animal models of membranous nephropathy, stimula...

Membranous nephropathy (MN) most commonly is idiopathic, but secondary causes are common in children and in older adults. The most common secondary causes of MN in industrialized countries include malignancy and systemic lupus erythematosis. Infectious causes (hepatitis B, quartan malaria, schistosomiasis) remain the most common etiologies in endemic areas. In this article we describe the clini...