نتایج جستجو برای: id50

تعداد نتایج: 265  

Journal: :Chemical & pharmaceutical bulletin 2001
H Mansuri-Torshizi S Ghadimy N Akbarzadeh

Two neutral complexes of formula [M(bpy)(cbdca)] [where M is palladium(II) (Pd(II)) or platinum(II) (Pt(II)), bpy is 2,2'-bipyridine and cbdca is anion of 1,1-cyclobutanedicarboxylic acid] have been synthesized. These water soluble complexes have been characterized by chemical analysis and conductivity measurements as well as 1H-NMR, ultraviolet-visible and infrared spectroscopy. In these compl...

2016
Yvonne J. Rosenberg David C. Montefiori Celia C. LaBranche Mark G. Lewis Markus Sack Jonathan P. Lees Xiaoming Jiang

Intravascular delivery of broadly neutralizing antibodies (bnAbs) has shown promise for prevention and treatment of HIV infection. However, multiple IV administrations in geographic locations with poor accessibility to medical care have practical limitations. We have assessed the efficacy of plant-derived PGT121 delivered subcutaneously (SC) against pre-and post-intravaginal challenge using a r...

Journal: :The Journal of infectious diseases 1998
C Coyle M Kent H B Tanowitz M Wittner L M Weiss

Therapy for microsporidia, which cause diarrhea and a wasting syndrome in persons with AIDS, has had limited success. Fumagillin, a naturally secreted water-insoluble antibiotic, has in vitro activity against microsporidia and has been used successfully in the treatment of superficial keratitis in patients with AIDS, but systemic therapy has been limited by toxicity of the currently available f...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2003
Louisiane F V Bresciani Jacks P Priebe Rosendo Augusto Yunes Jacir Dal Magro Franco Delle Monache Fátima de Campos Marcia Maria de Souza Valdir Cechinel-Filho

This work describes the phytochemical analysis and analgesic activity of a non polar fraction obtained from Adiantum cuneatum grown in Brazil. The results showed that the hexane fraction as well as two pure compounds, identified as filicene (1) and filicenal (2), given intraperitoneally, exhibited potent analgesic activity when evaluated in two models of pain in mice, writhing test and formalin...

Journal: :Journal of neurovirology 2000
H Fukushi A Taniguchi K Yasuda T Yanai T Masegi T Yamaguchi K Hirai

An acute and lethal infection of equine herpesvirus 9 (EHV-9), a new type of equine herpesvirus, was established in Syrian hamsters by intranasal inoculation. Clinical symptoms included the loss of body weight, nasal and ocular discharges and apparent neurological symptoms. Both LD50 and ID50 were equal at 33 plaque forming units. Histological and immunohistochemical examination demonstrated th...

Journal: :British journal of pharmacology 1975
H Barth W Lorenz H Troidl

1 Amodiaquine was found to be a potent inhibitor in vitro of gastric histamine methyltransferase from human and canine corpus and from pig antrum. The ID50 for the enzyme, purified from pig antrum mucosa by ultracentrifugation and chromatography on DEAE-cellulose, was 2.5 muM. 2 In six dogs with Heidenhanin pouches the maximum secretory response to histamine (40 mug/kg i.m.) was augmented by i....

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2000
V Cechinel Filho K L da Silva M M de Souza A E Oliveira R A Yunes C L Guimarães L G Verdi E L Simionatto F Delle Monache

This paper describes the isolation, identification and analgesic activity of a new biflavonoid from Rheedia gardneriana leaves, which correspond to I3-naringenin-II8-4'-OMe-eriodictyol (GB-2a-II-4'-OMe) (1), with a methoxyl group in position 4 of ring-II. Its structure was determined by spectroscopic data and confirmed by an alkaline hydrolysis. Its analgesic effect was evaluated in a writhing ...

Journal: :Investigative ophthalmology & visual science 1990
D A Lee T C Lee A E Cortes S Kitada

Scar formation and fibrosis are the most common causes of ultimate glaucoma filtration surgery failure. The authors used Coulter counter, hexosaminidase, and 3H-thymidine assays to evaluate the effects of mithramycin, mitomycin, daunorubicin, and bleomycin on human subconjunctival fibroblast growth in tissue culture. Fifty percent inhibitory doses (ID50) for each drug on different days of incub...

Journal: :Investigative ophthalmology & visual science 1986
A S Hajek R K Parrish K S Mallick M Gressel

Cytosine arabinoside (ara-C), a cell cycle-phase specific antimetabolite, was tested in a tissue culture model of human scleral fibroblasts (HSCF), and human retinal pigmented epithelium cells (HRPE), to investigate possible applications in the modulation of wound healing after glaucoma filtering surgery and in the postoperative management of proliferative vitreoretinopathy. Cell proliferation ...

Journal: :In vivo 2009
Antoaneta Ivanova Julianna Serly Dragomir Dinchev Imre Ocsovszki Ivanka Kostova Joseph Molnar

BACKGROUND Cytotoxic activity of saponins and phenolic compounds have been described in the literature, but no reports were found on their multidrug resistance (MDR)-modulating effects on human mdr1 gene-transfected mouse lymphoma cell line. MATERIALS AND METHODS Methylprototribestin, structurally related compounds and a mixture of 3 acetylated isomers of methylprotodioscin were investigated ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید