نتایج جستجو برای: ibandronate
تعداد نتایج: 387 فیلتر نتایج به سال:
10.2217/14750708.2.2.179 © 2 part of Osteoporosis is a common, increasingly prevalent condition worldwide. Osteoporotic fractures are associated with substantial morbidity, mortality, and health service resource use. Current daily oral and weekly bisphosphonates are highly effective in managing osteoporosis but patients often fail to take their medication correctly and/or stop treatment prematu...
INTRODUCTION Skeletal metastases are the most common complication of malignancies such as breast and prostate cancers [1]. In tumour-induced osteolysis, bone resorption is increased by the neoplastic activation of osteoclasts which results in rapid bone loss, change in the architectural integrity and ultimately, the load-bearing capacity of the affected bone. Fracture risk is increased by this ...
Continuing Bisphosphonate Osteoporosis Medications A ll bisphosphonates (alendronate, risedronate, ibandronate, and zoledronic acid) strengthen bone and reduce risk of fractures by slowing bone turnover. Beyond the first 5 years of use, however, benefits are much less clear. New reports of unusual fractures of the thigh bone after 3 or more years of bisphosphonate therapy have led to the recomm...
Neuroblastoma is the second most common solid tumor in childhood and frequently metastasizes to the bone marrow and the bone matrix. The mechanism involved in bone metastasis and destruction in neuroblastoma is poorly understood. Using a model of bone invasion in immunodeficient mice, we demonstrated that neuroblastoma cells recruited osteoclasts to generate osteolytic lesions and invade the bo...
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