Chenodeoxycholic acid (CDCA), in contrast to cholic acid (CA), reduces cholesterol saturation of bile. The mechanisms for these differences were the object of this study. Investigations were carried out in nine white men; three nonobese subjects and one obese subject were fed a weight-maintenance diet, and five obese patients had a reduced caloric intake for weight reduction. They were given a ...

In seven patients who underwent Fontan procedures but in whom no valves were inserted, dynamics of right heart flow were evaluated with the use of a catheter-tipped velocity transducer, pulsed Doppler echocardiography, and angiocardiography. Right atrial (RA) contraction caused a forward flow to the pulmonary artery (PA) and a backward flow to the inferior vena cava (IVC). Backward flow to the ...

Intracellular glutathione (GSH) has been implicated as a regulatory determinant of multidrug resistance protein (MRP) function. The objective of the present study was to evaluate in vivo the ability of D,L-buthionine-(S,R)-sulfoximine (D,L-BSO), a potent inhibitor of GSH biosynthesis, to reverse MRP-mediated drug resistance to doxorubicin. Athymic nude mice (nu/nu) bearing advanced parental hum...

SUMMARY: Rebound intracranial hypertension is a complication of epidural blood patching for treatment of intracranial hypotension characterized by increased intracranial pressure, resulting in potentially severe headache, nausea, and vomiting. Because the symptoms of rebound intracranial hypertension may bear some similarity to those of intracranial hypotension and literature reports of rebound...

Understanding mechanisms of reversibility in of hippocampal atrophy has taken on increased importance as the relationship between cortisol dysregulation and atrophy has become increasingly clear. Cushing’s disease provides a compelling model for understanding these mechanisms, particularly as atrophy is reversible following treatment to reduce the hypercortisolemia. The present study focused on...

•The discovery of two new species, Enallopagurus provenzanoi, and EnallopaguropsLs williamsi, has required an addendum and concluding part to the revisionary study of the "Pylopagunis-Tomopagurus" group of genera. The diagnoses of Enallopagurus McLaughlin and Enallopaguropsis McLaughlin, are emended, and a corrected key to the genera is provided. The discovery of additional specimens of Phimoch...

The widespread use of information technoiogy (IT) to create electronic linkages among supply chain panners with the objective of reducing transaction costs Journal of Managcmeni Information Sy.srem.t /Whner 2004^5. Vol. 21. No. 3. pp. 7-45. 0 2()1).'5 M.E. Shaipclnc. 0742-1222 / 2005 $9.50 + 0.00. 8 GOSAtN, MALHOTHA, AND EL SAWY may have unintended adverse effects on supply chain flexibility. I...