Prolonged coma resulting from hypoxic brain injury is usually associated with a dismal chance of return to independent existence. In this report a case is described of a 60 year old man who recovered and returned to work as a university professor after being in a vegetative state at least 8 weeks after a prolonged cerebral hypoxic event.

Introduction Perinatal hypoxia-ischemia affects approximately 2 to 4 per 1,000 term infants and a much greater proportion of preterm infants. Despite improved methods of intrapartum monitoring and advances in neonatal care and treatment, neonatal hypoxic-ischemic injury produces significant morbidity and mortality, often leading to long-term neurologic consequences. Neurologic sequelae of hypox...

BACKGROUND Preoperative brain injury is an increasingly recognized phenomenon in neonates with complex congenital heart disease. Recently, reports have been published that associate preoperative brain injury in neonates with transposition of the great arteries with the performance of balloon atrial septostomy (BAS), a procedure that improves systemic oxygenation preoperatively. It is unclear wh...

traumatic brain injury (tbi) is one the most common cause of disability between young adults. these people have been socially isolated during post-surgery traumatic brain injury. in this study we investigated the effect of social isolation on the structural deficits after tbi in the young rats. young rats were divided into control group with social interaction, sham group with social isolation ...

Progesterone (PROG) has been shown to exhibit a protective function against hypoxic-ischemic brain damage. The aim of the present study was to study the effects of PROG in a neonatal rat model of hypoxic-ischemic brain injury. A total of 30 Wistar rats, aged 7 days, were randomly divided into three groups: Sham, model and PROG. The rats in the model and PROG groups underwent a left common carot...

Background The clinical and radiological aspects of hypoxic brain injury without ischemia are not well characterized. There is a vast spectrum of clinical manifestations observed in patients that recover from brain hypoxia, including a subset demonstrating persistent motor system disturbances. Early Magnetic Resonance Imaging (MRI) studies have shown abnormalities in basal ganglia, cerebral and...

BACKGROUND AND PURPOSE As amide proton transfer imaging is sensitive to protein content and intracellular pH, it has been widely used in the nervous system, including brain tumors and stroke. This work aimed to measure the lactate content and amide proton transfer values in the basal ganglia of a neonatal piglet hypoxic-ischemic brain injury model by using MR spectroscopy and amide proton trans...

Purpose: Hypoxic-ischemic brain injuries influence the mechanisms of signal transduction, including mitogen-activated protein kinase (MAPK) that regulates gene expression through transcription factor activity. Several attempts have been made to use bee venom (BV) to treat neurological diseases. However, limited data are available for brain injuries such as neonatal hypoxic-ischemic encephalopat...

The developing brain is susceptible to hypoxic damage because of its high oxygen and energy requirements. Hypoxia-induced inflammatory response has been recognized as one of the main culprits in the development of hypoxic brain injury. In this regard, a hallmark feature is microglial activation which results in overproduction of inflammatory cytokines, free radicals and nitric oxide. Concomitan...

The neuronal cell death associated with perinatal asphyxia, or hypoxicischemic (HI) brain injury, plays an important role in neonatal mortality and neurodevelopment retardation. The types of cell death associated with HI in the brain have been classified as being either apoptotic or necrotic. Here we describe the recent discoveries of multiple non-apoptotic cell death pathways: necroptosis; fer...