This article was focused on the evaluation of protein biomarkers related to thrombosis, hypoxia, angiogenesis, and tissue remodeling in tear fluid patients with non-penetrating corneal trauma. 32 injures were enrolled study, control group consisted 15 healthy patients. Samples collected from volunteers use a disposable end micropipette. Protein levels D-dimer, hypoxia-inducible factor 1α (HIF-1...

Echinomycin (EKN), an inhibitor of hypoxia-inducible factor (HIF)-1 DNA-binding activity, has been implied as a possible therapeutic agent in ischemic diseases. Here, we assess EKN hypoxia-driven responses vitro using human primary adult retinal pigment epithelium cells (aRPE) and endothelial (hREC), vivo the laser-induced mouse choroidal neovascularization (CNV) model. Effects on hypoxia-media...

Background: Studies have shown that long non-coding RNAs (lncRNAs) are found to be hypoxia-regulated lncRNAs in cancer. Lung adenocarcinoma (LUAD) is the leading cause of cancer death worldwide, and despite early surgical removal, has a poor prognosis high recurrence rate. Thus, we aimed identify subtype classifiers construct prognostic risk model using hypoxia-associated noncoding (hypolncRNAs...

Objectives: Hypoxia results from the unavailability of sufficient oxygen to tissues. Since previous studies have shown that hypoxia in inflammation, this research has found it necessary investigate impact chronic on lungs and blood mice also potential benefit minocycline which is a well-known antibiotic.
 Design: Thirty were split into 5 groups 6 animals each. A physical model was used. He...

Declining oxygen concentrations in aquatic habitats represent extreme conditions that threaten benthic life. Hypoxia has recently become an important research topic, as areas affected by these phenomena are spreading globally. Omura Bay is one of the most highly enclosed seas Japan, and severely hypoxic occur at bottom every summer. We conducted a preliminary study center bay to evaluate how se...

Abstract Hypoxia is an essential topic in medical or biological sciences. The main aims of the present study were to examine most important articles (i.e., top 100 cited) on hypoxia. We how Nobel-prize awarded hypoxia inducible factor (HIF)-pathway discovery early 1990s has changed thematic composition this body literature, with a special emphasis studies linking and cancer. searched Pubmed for...

Many fish encounter hypoxia on a daily cycle, but the physiological effects of intermittent hypoxia are poorly understood. We investigated whether acclimation to constant (sustained) hypoxia or to intermittent diel cycles of nocturnal hypoxia (12 h normoxia:12 h hypoxia) had distinct effects on hypoxia tolerance or on several determinants of O2 transport and O2 utilization in estuarine killifis...

Mediator contributions to hypoxic dilation of rat gracilis muscle resistance arteries were determined by measuring dilation, vascular smooth muscle hyperpolarization, and metabolite production after incremental hypoxia. Nitric oxide (NO) synthase inhibition abolished responses to mild hypoxia, whereas COX inhibition impaired responses to more severe hypoxia by 77%. Blocking 20-hydroxyeicosatetr...