We present a novel method for interleaving planning with execution, called iterative deepening in hypotheticals. The method consists of performing an iterative deepening search in the space of partially ordered hypothetical plans. Hypothetical plans are partial plans in which the achievement of an otherwise unachievable goal may be conditioned on certain outcomes of sensing. This approach has b...

This contribution presents an updated analysis of the evolution of ribosome-inactivating proteins (RIPs) in plants. All evidence suggests that an ancestor of modern seed plants developed the RIP domain at least 300 million years ago. This ancestral RIP domain gave rise to a direct lineage of type 1 RIPs (i.e., primary type 1 RIPs) still present today in many monocots and at least one dicot. In ...

INDUCTION of a lysogenic bacterium can be defined as an event that results in a change in the host phenotype attributable to the presence of a prophage. The consequences of induction of K-12 ( A ) include loss of immunity to A, cell death, and synthesis of phage-specified enzymes. Increased synthesis of h mRNA occurs shortly after exposure of a lysogen to an inducing agent (ATTARDI et at. 1963;...

Atypical enteropathogenic Escherichia coli (aEPEC) are heterogeneous strains in terms of serotypes, adherence patterns and the presence of novel virulence factors. This heterogeneity is intriguing, promoting studies trying to characterize these novel proteins and to better comprehend this pathotype group. In a previous study analyzing low-molecular mass proteomes of four representative aEPEC st...

UNLABELLED Assigning functions to proteins of unknown function is of considerable interest to the proteomic researchers as the genes encoding them are conserved over various species. Here, we describe HypoDB, a database of hypothetical genes and proteins in six eukaryotes. The database was collected and organized based on the number of entries in each chromosome with few annotations. Hypothetic...

Melioidosis is an infectious disease caused by the pathogenic bacterium Burkholderia pseudomallei. Whole-genome sequencing revealed that the B. pseudomallei genome includes 5855 coding DNA sequences (CDSs), of which ∼25% encode hypothetical proteins. A pathogen-associated hypothetical protein, BPSL1038, was overexpressed in Escherichia coli, purified and crystallized using vapour-diffusion meth...