PURPOSE To investigate the frequency of lung cancer in patients with pulmonary hamartomas and to evaluate clinical, radiological, and pathological characteristics of pulmonary hamartomas. BASIC PROCEDURES We reviewed pathology records of pulmonary hamartomas diagnosed between 2003 and 2014. Medical records and the hospital electronic database were also reviewed for each patient to obtain clin...

Daichi Sone *, Takanobu Kaido , Masako Watanabe , Yoshiko Murata , Go Taniguchi , Taisuke Otsuki c Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8551, Japan Department of Neuropsychiatry, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan 7-3-1, Hongo, Bunkyo, Tokyo 113-8654, Japan Department of Neuros...

AIM We describe the clinical features, treatment and prognosis in a series of patients with epilepsy secondary to hypothalamic hamarthomas (HH) in a developing country. MATERIALS AND METHODS Eight patients with epilepsy and HH were included between 1997 and 2006. We analyzed gender, age, age at seizure onset (ASO), seizure types (ST), mental retardation (MR), precocious puberty (PP), electroe...

Neeraj N. Baheti, DM Ajith Cherian, DM Ramshekhar Menon, DM Ashalatha Radhakrishnan, DM A 21-year-old man presented with brief spells of inappropriate laughter since 6 years of age. Three gelastic seizures were recorded during video-EEG monitoring (video on the Neurology Web site at www.neurology. org). MRI revealed a small hypothalamic hamartoma (figure 1). Gelastic seizures can also arise fro...

Gelastic seizures have been described in various epilepsies arising from the temporal or frontal lobes, although the most commonly encountered form is related to the presence of an hypothalamic hamartoma. We report a patient with gelastic seizures involving the right parietal lobe. Our patient, a 32-year-old man, underwent video-EEG monitoring, interictal and ictal brain SPECTs during gelastic ...

PURPOSE Predicting seizure control after epilepsy surgery is difficult. The objectives of this work are: (a) to estimate the value of surgical procedure, presence of neuroimaging abnormalities, need for intracranial recordings, resection lobe, pathology, durations of epilepsy and follow-up period to predict postsurgical seizure control after epilepsy surgery and (b) to provide empirical estimat...

Radiosurgery is an emerging and interesting treatment option for several types of drug-resistant epilepsies. Particularly, CyberKnife radiosurgery may represent a therapeutic approach for mesial temporal lobe epilepsies, as well as epilepsies due to hypothalamic hamartomas and arteriovenous malformations. There are many reports in the literature, but precise patient selection, dosimetry, target...

Antonio J. da Rocha, PhD Marcos Rosa Junior, MD Fernando Norio Arita, PhD Isolated hypothalamic hamartomas (HH) have a distinct clinical phenotype from that of PallisterHall syndrome (PHS), as HH consist of more severe seizures and cognitive, behavioral, and endocrine disorders.1 The imaging features help one to distinguish these conditions (figures 1 and 2). Isolated HH are hyperintense on flu...

BACKGROUND Hypothalamic hamartomas (HHs) are congenital lesions composed of neurons and astroglia. Frequently, HHs cause central precocious puberty (CPP) and/or gelastic seizures. Because HHs might express genes similar to those required for the initiation of normal puberty, we used cDNA arrays to compare the gene expression profile of an HH associated with CPP with three HHs not accompanied by...

We describe two cases of hypothalamic hamartoma associated with arachnoid cysts. One case was initially documented on prenatal MR images. Because of the rarity of the association and resultant distortion in regional anatomy, the solid component of the mass may be overlooked. This would certainly be true when using lower-resolution diagnostic studies such as fetal MR imaging. The lesion could al...