tyrosinase has been recognized as a major autoantign in human vitiligo. here we have shown that experimental autoimmune vitiligo can be induced by intradermal injection of mushroom tyrosinase emulsified in complete freund’s adjuvant in c57bl/6 mice. the onse of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. our results con...

Over 120 patients of CML or GIST are being treated with imatinib at our institute since 2001. For the last one year, during routine outdoor visits, many patients have been reporting that their skin was becoming fairer while on imatinib. We interviewed 26 patients regarding this side effect; 22 of the patients and their relatives confirmed this experience at varying durations of treatment (media...

purpose: to report a case of hermansky-pudlak syndrome (hps). case report: a 7-year-old boy presented with marked generalized hypopigmentation, eye deviation and nystagmus. in addition he had history of easy bruising. visual acuity was 20/200. he had markedly translucent green irides, hypermetropic astigmatism, horizontal nystagmus and marked exotropia. funduscopy revealed a hypopigmented retin...

Vitiligo is a pigmentation disorder involving 1% of the population. One of the first line depigmenting agents is monobenzyl ether of hydroquinone (MBEH). Repigmentation following sun exposure; however, can occur after successful treatment with MBEH. This study describes a 54-year-old gentleman who presented with a 7-year history of hyperpigmented lesions on his face following depigmentati...

The Q-switched 1064-nm neodymium-doped yttrium aluminum garnet (QS 1064-nm Nd:YAG) laser is increasingly used for nonablative skin rejuvenation or "laser toning" for melasma. Multiple and frequent low-fluence, large-spot-size treatments are used to achieve laser toning, and these treatments are associated with the development of macular hypopigmentation as a complication. We present a case seri...