RNA binding motif protein 17 (RBM17) is a protein-coding gene. The protein encoded by RBM17 is involved in the regulation of alternative splicing and is overexpressed in cancer. The present study aimed to determine the effect of RBM17-knockdown in hypopharyngeal carcinoma FaDu cells using the lentivirus-mediated shRNA method. Cell proliferation was detected by an MTT assay. Flow cytometry analy...

RECQL1 and WRN proteins are RecQ DNA helicases that participate in suppression of DNA hyper-recombination and repair. In this study, we report evidence supporting their candidacy as cancer therapeutic targets. In hypopharyngeal carcinomas, which have the worst prognosis among head and neck squamous cell carcinomas (HNSCC) that are rapidly rising in incidence, we found that RECQL1 and WRN protei...

From 1965-1978 over 2,700 patients were admitted to the Massachusetts Eye and Ear Infirmary or the Massachusetts General Hospital with carcinoma of the oropharynx, larynx or nasopharynx; only 36 of these patients were less than 40 years of age. Twelve patients had oropharyngeal carcinoma, 13 patients had laryngeal or hypopharyngeal carcinoma, and 11 patients had nasopharyngeal carcinoma. Analys...

OBJECTIVE To identify the predictive factors (with emphasis on diagnostic delay) associated with the diagnosis of an advanced-clinical stage head and neck cancer. DESIGN Cross-sectional study of patients with head and neck cancer originally recruited for a case-control study. SETTING Three referral oncological centers in metropolitan areas in southern Brazil: São Paulo, Curitiba, and Goiâni...

Objectives: The main objective of this study is to report on the survival rates head-and-neck cancer cases seen in Tata memorial hospital (TMH). Materials and Methods: In present comprises a large number TMH, Mumbai, during years 2012– 14. included 4351 oral cancer, 766 oropharyngeal 612 hypopharyngeal 544 laryngeal cancers, 244 nasopharyngeal cancer. TNM group staging was used determine clinic...

BACKGROUND AND OBJECTIVES Total thyroidectomy is indicated in most cases with postcricoid carcinoma, circumferential hypopharyngeal carcinoma and in advanced laryngeal carcinoma. Persistent hypoparathyroidism is a frequent complication after total thyroidectomy which is difficult to manage unlike hypothyroidism. This study was to assess the feasibility of parathyroid gland autotranplantation af...