BACKGROUND It has been suggested that inhaled corticosteroids may provide greater protection against constrictor stimuli that act indirectly such as exercise than those that act directly such as histamine. METHODS The effects of six weeks treatment with inhaled budesonide (800 micrograms twice daily) on bronchial reactivity to histamine, exercise, and eucapnic voluntary hyperventilation of dr...

Hypoxia elicits hyperventilation and hypothermia, but the mechanisms involved are not well understood. The nitric oxide (NO) pathway is involved in hypoxia-induced hypothermia and hyperventilation, and works as a neuromodulator in the central nervous system, including the locus coeruleus (LC), which is a noradrenergic nucleus in the pons. The LC plays a role in a number of stress-induced respon...

UNLABELLED Hyperventilation performed by athletes during preparation for resistance exercise might contribute to reports of postexercise orthostatic instability. PURPOSE To test the hypothesis that post-resistance exercise orthostatic instability is associated with exaggerated reductions of cerebral blood-flow velocity after hyperventilation. METHODS We recorded the ECG, end-tidal CO2, beat...

Anxiety-induced hyperventilation syndrome (HVS) is common, affecting 10% of the population with a female predominance and maybe continuous or episodic [1,2]. It forms part of the “dysfunctional breathing” group which includes vocal cord dysfunction, phobic disorders and panic attacks most of which are associated with hyperventilation [3]. Dysfunctional breathing arises frequently in asthma and ...

OBJECTIVES To assess the effect of hyperventilation and mental stress on coronary blood flow and symptom production in patients with syndrome X. DESIGN A prospective study. Hyperventilation and mental stress tests were performed on the ward and were repeated in the cardiac catheter laboratory where coronary blood flow velocity was also measured with an intracoronary Doppler catheter in the le...