To the Editor: In the very interesting review published in Circulation dealing with cardiac complications of chemotherapy with a focus on myocardial complications, the authors did not refer to the cardiac hypersensitivity that is associated with chemotherapy. Acute cardiovascular events associated with hypersensitivity to chemotherapeutic drugs pose a real threat for the myocardium. Rare and ve...

Background Aspirin (ASA) hypersensitivity is frequent in patients with chronic rhinosinusitis and nasal polyps (CRSwNP), which is called aspirin exacerbated respiratory disease (AERD). However, there are few studies on evaluating the prevalence of ASA hypersensitivity in patients with nasal polyps (NPs), using the oral aspirin challenge test. This study was designed to determine the frequency o...

Despite the important role of both cyclooxygenase (COX) isoforms (i.e. COX-1 and COX-2) in maintenance of hypersensitivity following peripheral nerve injury, their role in the development of neuropathic pain is not clear. The present study was undertaken to determine the effect of COX inhibitors to address the potential role of COX isozymes in the development of neuropathic pain in rats after c...

determine the incidence of intraoperative hypersensitivity events in one U.S. surgical center. The authors concluded that the overall incidence of anaphylaxis was 1 in 4,583 surgeries, whereas that of hypersensitivity was 1 in 677. However, major methodologic issues should be highlighted, and the results must be debated because no conclusion can be effectively drawn from this study. First, the ...

Diurnal variations in pain hypersensitivity are common chronic disorders. Temporal exacerbation of neuropathic is dependent on diurnal glucocorticoid secretion from the adrenal glands. We previously demonstrated that spinal expression serum- and glucocorticoid-inducible kinase-1 (SGK-1) associated with glucocorticoid- induced hypersensitivity, but there no available strategies to inhibit SGK-1 ...