Christianson syndrome (CS) is an X-linked neurodevelopmental/neurological disorder characterized in males by the following core symptoms that include nonverbal status, intellectual disability, epilepsy, truncal ataxia, postnatal microcephaly and hyperkinesis. CS is caused by mutations in the SLC9A6 gene which encodes a multi-pass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) prot...

Christianson syndrome (CS) is an X-linked neurodevelopmental and neurological disorder characterized in males by core symptoms that include non-verbal status, intellectual disability, epilepsy, truncal ataxia, postnatal microcephaly and hyperkinesis. CS is caused by mutations in the SLC9A6 gene, which encodes a multipass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) protein, func...

Although impairment of left ventricular function in acute myocardial infarction is closely related to extent of necrosis, function in the noninfarct zone also contributes to global performance and thus may be of prognostic importance. We evaluated left ventricular regional wall motion by the centerline chord method in 332 patients treated with intravenous tissue-type plasminogen activator (t-PA...

A 77-year-old woman was referred for a dobutamine stress test. She had a prior history of hypertension. Basal ECG was normal (Figure 1A). At 40 g kg 1 min 1 she developed typical chest pain with ST-segment elevation in DI, DII, and the anterior leads with ventricular bigeminy (Figure 1B and 1C). The echocardiogram showed apical and mid-wall myocardial segment akinesis with basal hyperkinesis an...

Epilepsy with continuous spikes and waves during slow sleep (CSWS), which is one of the prototypes of electrical status epilepticus during slow wave sleep (ESES), is a rare disease that affects children and is associated with deterioration of one or more cognitive functions, behavioral disturbances, spike and spike-wave discharges increased during slow wave sleep, and epileptic seizures. The pa...

BACKGROUND Typical or classical takotsubo cardiomyopathy (TCM) is associated with the characteristic abnormality of a ballooned left ventricular apex with basal segmental hyperkinesis. TCM may not present with the "classical" wall motion abnormalities but can have a variety of segmental wall motion abnormalities. The aim of our work was to assess for any unique identifying factors that can help...

A 74-year-old woman, without a history of cardiolog-ical problems or risk factors of cardiovascular diseases, was admitted to the emergency room of our hospital after 2 h of chest pain. During the transport, the patient received 5000 U of unfractionated heparin, aspirin (300 mg) and clopidogrel (600 mg). The patient had suffered from an anxiety syndrome for several years. At admission, the pati...

INTRODUCTION First described in Japan, takotsubo cardiomyopathy is increasingly becoming recognized worldwide as a cause of sudden and reversible diminished left ventricular function characterized by left apical ballooning and hyperkinesis of the basal segments, often with symptoms mimicking a myocardial infarction. Associated with physical or emotional stress, its exact pathogenesis has not be...

A 73-year-old Japanese woman was admitted to the intensive care unit of our hospital with the diagnosis of eosino-philic pneumonia and congestive heart failure. Laboratory examination revealed a white blood cell count of 8100/mm 3 with 49% eosinophils, 1568 IU/mL IgE, 467 IU/L lactate dehydrogenase with 40% lactate dehydrogenase-1, a brain natriuretic peptide level of 1223 pg/mL, and 23.5 U/mL ...

To study regional wall motion early in the development of acute myocardial infarction, left ventriculograms performed in 24 patients before thrombolysis and within 3.5(1.2) (mean (SD] hours of the onset of pain were digitised frame by frame. Isometric and contour plots of regional wall motion were constructed. In 19 patients (seven with anterior descending, eight with right, and four with circu...