A sixteen year-old male patient with no history of consanguinity in the family, reported with patchy, thickened lichenified plaques over the whole body. Some areas had normal skin while some were Blaschkoid lesions. The child had delayed milestones along with hypogonadism. Digital contracture with palmoplantar keratoderma was present. Histopathology showed characteristic vacuolar degeneration o...

elephantiasis nostras verrucosa (env) is a rare condition in which hyperkeratosis, fibrosis and disfiguration of dermis occurs. it is caused mostly by non infectious diseases such as surgery, trauma, tumors, and venous obstructions. to our knowledge there is not any case report of env in middle east region. in this patient, env caused by trauma and patient presented with enlargement of right lo...

A 44-year-old man who presented with recent onset hyperkeratosis palmaris et plantaris was found to have a carcinoma of the bronchus.

O The aim of this study was to analyze the immunolabeling of two cell cycle protein regulators, p53 and p21WAF1, in non-dysplastic leukoplakias with different epithelial alterations: acanthosis, hyperkeratosis and acanthosis combined with hyperkeratosis, and compare them with dysplastic leukoplakias. Material and Methods: This was a prospective cohort study involving 36 patients with oral homog...

the inheritance of olmsted syndrome that is a very rare congenital with transgredient palmoplantar keratoderma is distinguished by the presence of massive hyperkeratosis with fissured skin and periorificial chaps. it usually appears during the early life and mostly in male pateints. herein we report a case of olmsted syndrome which is associated with ichthyosis and somatic type of delusion duri...