We propose a periodic-normal mixture (PNM) model to fit transcription profiles of periodically expressed (PE) genes in cell cycle microarray experiments. The model leads to a principled statistical estimation procedure that produces more accurate estimates of the mean cell cycle length and the gene expression periodicity than existing heuristic approaches. A central component of the proposed pr...

Our photometric monitoring revealed that DW Cnc, which was originally classified as a dwarf nova (V = 15– 17.5), remained at a bright state of Rc = 14.68 ± 0.07 for 61 days. In conjunction with optical spectra lacking a strong He ii emission line, we propose that the object is not a dwarf nova, but a non-magnetic novalike variable. Throughout our monitoring, the object showed strong quasi-perio...

In this study, we examined the usefulness of arterial blood gas variables, as changed by the hypoxic stimulus, in discerning various experimentally-induced conditions of diaphragm weakness in anesthetized cats. We defined three experimental situations (models): (i) intact muscle, statistical Class I, (ii) four degrees of muscle dysfunction (after sequential diaphragm denervation), Classes II-V,...

We use data from the Rossi X-ray Timing Explorer to search for harmonics and sidebands of the two simultaneous kilohertz quasi-periodic oscillations (kHz QPOs) in Sco X-1. We do not detect any of these harmonics or sidebands, with 95% confidence upper limits to their power between ∼ 1% and ∼ 10% of the power of the upper kHz QPO. The oscillations produced at these frequencies may be attenuated ...

We suggest an explanation for the twin kilohertz quasi-periodic oscillations (kHz QPOs) in low-mass X-ray binaries (LMXBs) based on magnetohydrodynamics (MHD) oscillation modes in neutron star magnetospheres. Including the effect of the neutron star spin, we derive several MHD wave modes by solving the dispersion equations, and propose that the coupling of the two resonant MHD modes may lead to...

Thyrotoxic periodic paralysis (TPP) is characterized by the presence of muscle paralysis, hypokalemia, and hyperthyroidism. We report the case of a young man with paralysis of the lower extremities, severe hypokalemia, and concurrent hyperthyroidism. TPP was suspected; therefore, treatment consisting of judicious potassium (K+) repletion and β-blocker administration was initiated. However, urin...

Spinal cord hemisection at C2 (C2HS) severs bulbospinal inputs to ipsilateral phrenic motoneurons causing transient hemidiaphragm paralysis. The spontaneous crossed-phrenic phenomenon (sCPP) describes the spontaneous recovery of ipsilateral phrenic bursting following C2HS. We reasoned that the immediate (next breath) changes in tidal volume (V(T)) induced by ipsilateral phrenicotomy during spon...

OBJECTIVES Investigations into the epidemiology of acute flaccid paralysis (AFP) are an essential strategic component of the Global Poliomyelitis Eradication Initiative of the World Health Organization (WHO), and are part of the certification process for polio eradication worldwide. This is an epidemiological report of AFP incidence in children less than 15 years old in southwest Iran. METHOD...

We show how the simultaneous presence of a strong quasi periodic oscillation (QPO) of period ∼10 seconds in the optical and X-ray lightcurves of the X-ray transient XTE J1118+480 can be used to obtain information about the nature of the accretion flow around the source. The unusually high optical-to-X-ray flux ratio and the QPO observed simultaneously in both energy bands suggest that a signifi...

Waning immunity could allow transmission of polioviruses without causing poliomyelitis by promoting silent circulation (SC). Undetected SC when oral polio vaccine (OPV) use is stopped could cause difficult to control epidemics. Little is known about waning. To develop theory about what generates SC, we modeled a range of waning patterns. We varied both OPV and wild polio virus (WPV) transmissib...