INTRODUCTION Hyperkalemia is a serious medical condition that often manifests in patients with chronic kidney disease and heart failure. Renin-angiotensin-aldosterone system inhibitors are known to improve outcomes in these disease states but can also cause drug-induced hyperkalemia. New therapeutic options exist for managing hyperkalemia in these patients which warrant evidence-based evaluatio...

Background: Potassium, as an extracellular ion, plays an important role in the electrophysiologic function of the myocardium and any change in extracellular concentration of this ion might have a marked impression upon myocyte electrophysiologic gain. High serum potassium levels are thought to impair pulse conduction in Purkinje fibers and ventricles more than that in the Atrio...

INTRODUCTION Many of those who survive following an earthquake die in the next phase due to preventable and treatable medical conditions such as hyperkalemia. The present study aimed to evaluate the trend of potassium changes in crush syndrome patients of Bam earthquake. METHODS In this retrospective cross-sectional study, using the database of Bam earthquake victims, which were developed by ...

Hyperkalemia is a common, silent, and potentially lethal dinical condition. The pathophysiologic factors that bead to hyperkalemia are well understood, and the treatment is straightforward. Clinical management requires exclusion of pseudohyperkalemia, assessment of the urgency for treatment, and institution of appropriate therapy. Long-term treatment requires identification of the etiology and ...

BACKGROUND Most available quality indicators for hospitals are represented by simple ratios or proportions, and are limited to specific events. A generalized method that can be applied to diverse clinical events has not been developed. The aim of this study was to develop a simple method of evaluating physicians' prescription patterns for diverse events and their level of awareness of clinical ...

Inhibition of the renin-angiotensin-aldosterone system (RAAS) is a key strategy in treating hypertension and cardiovascular and renal diseases. However, RAAS inhibitors (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, aldosterone receptor antagonists, and direct renin inhibitors) increase the risk of hyperkalemia (serum potassium >5.5 mmol/L). This review evaluates the ...

The mineralocorticoid aldosterone, essential for maintaining body K + and Na balance, has different effects if secreted due to hypovolemia or hyperkalemia. Here, we used proteomics profile kidney distal convoluted tubule (DCT) cells isolated by a novel FACS approach from mice fed low-Na diet (mimicking hypovolemia) high-K hyperkalemia). study provides the first in-depth proteome of mouse DCT in...

Abstract In the present case with primary pseudohypoaldosteronism, severe hypekalemia was treated with salbutamol inhalation in acute phase. Transcellular hypokalemic effect of salbutamol is related to the activation of Na-K pump on the cell membrane. Although use of salbutamol inhalation in hyperkalemia was previously described, it has not been widely used. The administration of salbutamol by ...

Due to increasing reports of spironolactone associated life-threatening hyperkalemia, we implemented a rule in our automated event detection system to monitor serum potassium results in patients receiving spironolactone. In 2004, 419 (10.49%) of 3995 admissions at 3 BJC HealthCare hospitals were identified as having hyperkalemia while on spironolactone. For a 9-month period in one facility, 33 ...

Hyperkalemia is a severe life-threatening electrolyte disorder that commonly affects the cardiac conductivity and contractility. Ascending paralysis affecting the extremities with focal neurological deficit as well as quadriparesis and a seizure associated with hyperkalemia has been reported in the literature. Here, we describe a case of isolated recurrent lower extremity paralysis and an episo...