Many studies have attempted to correlate changes of motor cortex activity with progression of Parkinson's disease, although results have been controversial. In the present study we used intracortical microstimulation (ICMS) combined with behavioral testing in 6-hydroxydopamine hemilesioned rats to evaluate the impact of dopamine depletion on movement representations in primary motor cortex (M1)...

BACKGROUND Parkinson's disease (PD) is typically characterized by impairment of motor function. Gait disturbances similar to those observed in patients with PD can be observed in animals after injection of neurotoxin 6-hydroxydopamine (6-OHDA) to induce unilateral nigrostriatal dopamine depletion. Exercise has been shown to be a promising non-pharmacological approach to reduce the risk of neuro...

In this study, histopathological and immunohistochemical evaluations were made on the damage to gastric tissue in peptic ulcer model induced by indomethacin, it was investigated whether plants Hypericum perforatum Rosa spinosissima have a therapeutic effect. order create an model, 25mg/kg indomethacin administered orally rats other groups, except sham control group, 2 doses, 24 hours apart. tre...

ABSTRACTParkinson’s disease (PD) is a neuropathological and debilitating disorder involving the degeneration of mesencephalic dopaminergic neurons. Neuroprotective effect of hesperetin has already been reported, therefore, this study examined whether the administration of this flavonoid would attenuate behavioral abnormalities in an experimental model of PD in rat. For this purpose, unilateral ...

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This paper argues that the physical being of one of John Searle's institutional facts is the totality of records of the fact, together with some very specific background activities and capacities. Abstract: This paper argues that the physical being of one of John Searle's institutional facts is the totality of records of the fact, together with some very specific background activities and capac...

Stamenković, J., Radojković, I., Đorđević, A., Jovanović, O., Petrović, G., Stojanović, G.: Optimization of HPLC method for the isolation of Hypericum perforatum L. methanol extract. Biologica Nyssana, 4 (12), December 2013: 81-85. St. John's Wort (Hypericum perforatum L.) is one of the most studied plant species in the family Hypericaceae. The aim of this study was the identification of the co...