OBJECTIVES The John Henryism (JH) hypothesis suggests that, under adverse social and economic conditions, high-effort coping styles that reflect hard work and determination may contribute to elevated blood pressure. Results from tests of this hypothesis have been mixed, with variations by region, urban versus rural areas, race, gender, and age. The majority of studies reporting that socioeconom...

ss Open Acce Proceedings Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci Heather J Cordell*1, Mariza de Andrade2, Marie-Claude Babron3, Christopher W Bartlett4, Joseph Beyene5, Heike Bickeböller6, Robert Culverhouse7, L Adrienne Cupples8, E Warwick Daw9, Josée Dupuis8, Catherine T Falk10, Saurabh Ghosh11, Katrina A Goddard12, Ellen L G...

The relationship between law and morality represents a major theme in jurisprudence and is the subject-matter of this article. I shall focus on the use of the criminal law to enforce morality and, in particular, I shall consider whether an identifiable line can be drawn between moral standards that may properly be the subject of legal enforcement and those that may not. This issue was, of cours...

Bartholomew's Hospital, where he had trained towards the end of the long career of John Abernethy, who attracted large numbers of students to his lectures. He had begun his medical career in the 1820s (L.S.A. 1824, M.R.C.S. 1825) and subsequently gained an F.R.C.S. by examination in 1847, and an M.D. from the University of St Andrews in 1856, during the course of his medical practice in Yeovil.

Hypericum perforatum L. (Hypericaceae) is one of the medicinal plants whose value has increased rapidly in recent years. It especially popular for its use treatment mild and moderate depression, as well skin diseases, internal external inflammatory wounds, neurological disorders, metabolism-disrupting effects free radicals. Besides, it shows inhibitory against different kinds microorganisms suc...

Hypericum perforatum L. is a medicinal plant considered as an important natural source of secondary metabolites with a wide range of pharmacological attributes. Hairy roots (HR) were induced from root segments of in vitro grown seedlings from H. perforatum after cocultivation with Agrobacterium rhizogenes A4. Investigations have been made to study the production of phenolic compounds in dark-gr...

Monoamine oxidase (MAO) catalyzes the oxidative deamination of amines and neurotransmitters and is involved in mood disorders, depression, oxidative stress, and adverse pharmacological reactions. This work studies the inhibition of human MAO-A by Hypericum perforatum, Peganum harmala, and Lepidium meyenii, which are reported to improve and affect mood and mental conditions. Subsequently, the an...

The pharmacological approach to the treatment of depression includes a long-term employment of antidepressants, either in the form of monotherapy or as a combination of several antidepressants with various mechanisms of action. Hypericum perforatum L. (St. John's wort) is the only natural antidepressant. Several constituents of the extract, such as hypericin and hyperforin, seem to be important...

John Hick has used revolutionary metaphors in recommending his pluralistic philosophy of religions. To turn from a focus on the particulars of one’s home religion to a focus on the universally available Real is, he famously says, a Copernican “revolution” in religious thought. Hick says that those religious adherents who abandon the traditional positions of exclusivism or inclusivism, positions...