PURPOSE The purpose of this study was to compare the effectiveness of midazolam (MDZ) alone to a combination of MDZ and hydroxyzine (MDZH) when sedating young children for dental treatment. METHODS This was a prospective, double-blinded, crossover clinical study of young uncooperative children in need of at least 2 restorative visits. Twenty-eight children, ages 21 to 56 months, with a mean a...

The purpose of this study was to determine differences in heart rate (HR), blood pressure (BP), peripheral oxygen saturation (pO2), expired CO2 (CO2), and behavior (using two scales) comparing nitrous oxide/oxygen (N2O) with oxygen (O2) alone in 20 children (mean age 45 +/- 5.1 months) sedated with chloral hydrate (CH) and hydroxyzine in a double-blind crossover design. Administration of CH (40...

CASE A 68-year-old woman presented with a pruritic, blistering rash. Three months prior, she had developed itchy lesions on her hands and feet, spreading to her chest and abdomen. For the past week, she had developed painful, tense blisters. The patient had seen her primary care doctor at symptom onset and failed to improve with topical clobetasol proprionate and hydroxyzine. She took amlodipin...

Because the therapeutic and toxic effects of oral therapy with bronchodilator drugs are poorly documented in patients with chronic obstructive pulmonary disease (COPD), we investigated the effects of administration of terbutaline (5 mg) and of a combination drug (Marax) containing ephedrine (25 mg), theophylline (130 mg), and hydroxyzine (10 mg) on pulmonary function, sevenhour taped electrocar...

Participants 334 outpatients diagnosed with generalised anxiety disorder (DSM-IV criteria) and a Hamilton Rating Scale for Anxiety (HAM-A) total score of at least 20. All were aged 18–65 years (mean 45 years); 68% women. Exclusion criteria were alcohol or drug dependence; major depressive episode within 6 months; score of 7 or above on the Raskin Severity of Depression and Mania scale; psychoti...