We have studied the formation and carried out an in vivo evaluation of carbonate apatite (CO3-Ap) and CO3-Ap/CaCO3 composite coatings on titanium substrates using the thermal substrate method. The coatings were formed on commercial pure titanium rods (diameter = 2mm, length = 5mm) and plates (thickness = 0.3mm) by the thermal substrate method in an aqueous solution that contained Ca(H2PO4)2, Ca...

Recent solubility, electrokinetic, spectroscopic and flotation studies in our laboratory on apatite and calcite in aqueous electrolytes indicate complex mineral_olution interactions which can alter surface characteristics of these minerals markedly in the presence of each other. In the case of systems containing such sparingly soluble minerals, understanding of the mineral_olution chemical equi...

Alkaline-heat-treated titanium self-forms an apatite surface layer in vivo. The aim of the present study was to materialistically characterize the surface of alkaline-heat-treated titanium immersed in simulated body fluid (AHS-TI) and to examine the differentiation behavior of osteoblasts on AHS-TI. SEM, thin-film XRD, FTIR, and XPS analyses revealed that AHS-TI contained a 1.0- micro m-thick, ...

It was believed for a long time that mRNA is very unstable, and can not be used for therapeutic purposes. In the last decade, however, many research groups proved its transfection feasibility along with advantages and applications. Our investigation is aimed at establishing a potent and efficient mRNA delivery system. We previously reported that an inorganic-organic hybrid carrier by exploiting...

Poly-L-lactide/β-tricalcium phosphate (PLLA/β-TCP) porous scaffold fabricated by freeze shrinking/particulate leaching was studied. The scaffold was immersed into simulated body fluid (SBF) for 1, 2, 3 and 4 weeks and analyzed by the SEM, XRD and FT-IR spectroscopy. The ability of inducing Ca-P formation was compared among the scaffolds with different content of βTCP. SEM shows a typical featur...