introduiction: this study aimed to investigate the protective effects of 12-week voluntary exercise using a running wheel on the striatum  dopaminergic neurons against 6-hydroxydopamine lesions in rats. materials and method: twenty five rats were divided into three groups including healthy, parkinson and training-parkinson. the training groups were housed in individual cages geared with running...

background and objective: parkinson's disease (pd) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. l-dihydroxyphenylamine (l-dopa) therapy is currently the gold standard maneuver for pd. due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of this age...