Gelatin-capped gold nano particles (GNPs) of diameter 23, 28 and 36 nm were prepared and characterized as almost monodispersed, near-spherical solids. In acidic media, these GNPs at their very low concentration level (∼10(-13) M) catalyze the oxidation of hydrazine by the metallo-superoxide, [(NH(3))(4)Co(III)(μ-NH(2),μ-O(2))Co(III)(NH(3))(4)](NO(3))(4) (1). In the presence of a large excess of...

BACKGROUND The aim of this study was to investigate the protective role of intranasally administered substance P-loaded gelatin nanoparticles (SP-GNPs) against 6-hydroxydopamine (6-OHDA)-induced apoptosis in vitro and in vivo, and to provide a new strategy for treating brain pathology, such as Parkinson's disease. METHODS SP-GNPs were prepared by a water-in-water emulsion method, and their st...

An evanescent-field-coupled waveguide-mode (EFC-WM) sensor utilizes monolithic SiO2/Si/SiO2 sensing plates having a multilayered structure and is used to evaluate a blocking agent comprising poly(ethylene glycol)-based block copolymers. Factor IX (FIX) protein was detected using its aptamer, viz. FIX was immobilized on a glutaraldehyde-modified silica surface, and then treated with a biotinylat...

Introduction: To date, gold nanoparticles (GNPs) have been demonstrated to have great potential as contrast agent for CT imaging and therapeutics. This study was designed to evaluate any effect on X-ray attenuation that might result from using GNPs with a variety of size, surface chemistries and shapes.   Materials and Methods: Spherical GNPs and gold nanorod...

The adsorption of catechol (1,2-dihydroxybenzene) on graphene nanoplatelets (GNPs) is investigated electrochemically and spectroscopically. The reversible adsorption of catechol on GNPs is Langmuirian with an adsorption constant of (0.2 ± 0.002) mM-1 at low adsorbate concentrations (≤100 mM). At higher concentrations (>100 mM) the adsorption of catechol on GNPs is shown to undergo a flat to ver...

Emerging resistance to antibiotics is a mounting worldwide health concern and increases the need for nonantibiotic strategies to combat infectious diseases caused by bacterial pathogens. In this study, the authors used the antibiofilm activity of the naturally occurring antimicrobial cinnamaldehyde (CNMA) conjugated to the surface of gold nanoparticles (GNPs) to deliver CNMA efficiently and era...

Gold nanoparticles (GNPs) have shown promising medical applications in cancer treatment involved in the regulation of intracellular redox balance. Previously, we have reported that GNPs can trigger apoptosis and necrosis in human lung cancer cells (A549) when L-buthionine-sulfoximine (BSO) was used to decrease the expression of intracellular glutathione (GSH). Herein, we investigated the cytoto...

Herein we report a simple, one-pot, surfactant-free synthesis of 3D Ag microspheres (AgMSs) in aqueous phase at room temperature. The 3D AgMSs act as supports to fix the gold nanoparticles (GNPs) in 3D space via the interaction between the carboxyl groups of GNPs and the Ag atoms of AgMSs. The ensemble of AgMSs@GNPs with high surface-enhanced Raman scattering (SERS) activity and sensitivity can...

Introduction: A main choice for cancer treatment is radiotherapy. But, the radiotherapy disadvantage is damages caused by radiation given to normal tissues/organs surrounding cancer. One way to avoid this is via increasing radiosensitization of cancer cells. Gold nanoparticles (GNPs) have shown sensitizing effect on cancer cells by enhancing their absorbed dose. Unlike earlier ...

Nowadays, modified electrodes with metal nanoparticles have appeared as an alternative for the electroanalysis of various compounds. In this study, gold nanoparticles (GNPs) were chosen as interesting metal nanoparticles for modifying of carbon paste electrode (CPE). GNPs and the gold nanoparticles-modified carbon paste electrode (GNPs/CPE) were characterized by UV-Vis spectroscopy, transmissio...