Fast Na+ channel inactivation is thought to involve binding of phenylalanine 1489 in the hydrophobic cluster IFM in L(III-IV) of the rat brain type IIA Na+ channel. We have analyzed macroscopic and single channel currents from Na+ channels with mutations within and adjacent to hydrophobic clusters in L(III-IV). Substitution of F1489 by a series of amino acids disrupted inactivation to different...

In this paper an application of the cluster analysis technique in educational planning is demonstrated by means of a developed computer software with some characteristics of an expert system. The main idea is based on the knowledge-based systems which have been applied in group technology. The software is applied to weekly schedules of the courses and professors of the Industrial Engineering De...

Clusters are geographically close groups of related companies or institutions related to a certain area which are inherently more efficient than the other companies due to advantages such as being located in one place, networks, external knowledge, variability of human capital, etc. Today, development through clusters plays a pivotal role in the economic and industrial policies of developed...

The hedgehog-shaped {Mo368} cluster shows unique electronic (extremely high extinction coefficient) and structural features, especially regarding its size, the high number of delocalized electrons which allows to measure the surface enhanced Raman scattering (SERS) spectrum and the option for coordination chemistry inside the cavity. Its relative instability in aqueous solution can be overcome ...

The prototype ferredoxin maquette, FdM, is a 16-amino acid peptide which efficiently incorporates a single [4Fe-4S]2+/+ cluster with spectroscopic and electrochemical properties that are typical of natural bacterial ferredoxins. Using this synthetic protein scaffold, we have investigated the role of the nonliganding amino acids in the assembly of the iron-sulfur cluster. In a stepwise fashion, ...

The influence of pH on the sorption of pentachlorophenol (PCP) onto three organic amendments, char, humic acid (HA) and peat, and the effect of organic amendments on PCP sorption to three kinds of soils were evaluated. The sorption of PCP on these sorbents fitted the Freundlich model well, suggesting that PCP sorption isotherms were nonlinear with exponential coefficient (N) value lower than 1....

purpose: to compare the optical properties of hydrophilic and hydrophobic intraocular lenses (iols) containing uv-absorber and to determine their chemical composition. methods: optical properties of different foldable hydrophilic and hydrophobic as well as non-foldable hydrophobic polymethylmetacrylate (pmma) iols were evaluated in three powers of 15, 22 and 25 diopters. optical properties were...

study of genetic relationships is a prerequisite for plant breeding activities as well as for conservation of genetic resources. in the present study, genetic diversity among and within 15 iranian native ajowan(carum copticum l.) populations were determined using inter simple sequence repeat (issr) markers. twelve selected primers produced 153 discernible bands, with 93 (60.78%) being polymorph...