Late-stage tritiation with high selectivity, isotopic purity and functional-group tolerance is important for the radiolabelling of drug candidates or bioactive compounds. Now, a broadly applicable protocol using aryl thianthrenium salts allows complex molecules by hydrogenolysis via an intermediate cationic palladium complex.

The gas-phase loading of [Zn4O(bdc)3] (MOF-5; bdc = 1,4-benzenedicarboxylate) with the volatile compound [Ru(cod)(cot)] (cod = 1,5-cyclooctadiene, cot = 1,3,5-cyclooctatriene) was followed by solid-state (13)C magic angle spinning (MAS) NMR spectroscopy. Subsequent hydrogenolysis of the adsorbed complex inside the porous structure of MOF-5 at 3 bar and 150 degrees C was performed, yielding ruth...

Activity improvement of Ru-based catalysts is needed for efficient production of valuable chemicals from glycerol hydrogenolysis. In this work, a series of Re promoted Ru catalysts encapuslated in porous silica nanoparticles (denoted as Re-Ru@SiO₂) were prepared by coating silica onto the surface of chemically reduced Ru-polyvinylpyrrolidone colloids, and were used to catalyze the conversion of...

Ni-based catalysts as replacement for noble metal catalysts are of particular interest in the catalytic conversion of biomass due to their cheap and satisfactory catalytic activity. The Ni/SiO2 catalyst has been studied for the hydrogenolysis of glycerol, and doping with phosphorus (P) found to improve the catalytic performance significantly because of the formation of Ni2P alloys. However, in ...

Five novel 3-hydroxyl derivatives of sixteen-membered macrolide possessing 4-O-acyl-alpha-L-cladinose as a neutral sugar moiety were synthesized by using a combination of structurally stable silyl acetal protection and selective hydrogenolysis of a 3"-methylthiomethyl ether to a 3"-OMe group. Several derivatives having n-butyryl, i-butyryl and n-valeryl substituent at the 4"-OH group exhibited ...

The nitro group in aromatic nitro compounds containing reducible substituents such as methyl, carboxylic acids and phenols, and halogens are selectively and rapidly reduced at room temperature to the corresponding amines in good yield by employing hydrazine glyoxylate in the presence of zinc powder or magnesium powder. It has been observed that hydrazine glyoxylate is more effective than hydraz...

Inspired by previous studies on model systems, a series of silica-supported Au–Ni catalysts were prepared and tested for the conversion of propane in the presence of hydrogen. The Au–Ni/SiO2 catalysts were prepared by successive impregnation, i.e. Ni was deposited first followed by Au. TEM/EDX results confirmed the presence of bimetallic Au–Ni nanoparticles. The dehydrogenation of propane to pr...