Transcriptional regulatory circuits provide only a fraction of the signaling pathways and regulatory mechanisms that control the bacterial cell cycle. The CtrA regulatory network, important in control of the Caulobacter cell cycle, illustrates the critical role of nontranscriptional pathways and temporally and spatially localized regulatory proteins. The system architecture of Caulobacter cell-...

Janssen TWJ. Effects of hybrid cycling on lower-body soft tissue composition, and proximal tibia and distal femur bone mineral density in inactive people with long-term spinal cord injury: a 16-wk randomized controlled trial. PLoS One. Abstract Objective: To investigate the effects of hybrid cycle exercise on soft tissue composition of the legs, proximal tibia and distal femur bone mineral dens...

The complexity of gene regulatory network models stems from the fact that the models should be able to represent continuous, discrete as well as stochastic aspects of gene regulation. Hybrid stochastic Petri nets are the models, which can fairly incorporate all these aspects while keeping the model as simple as possible for biologists. This paper constructs an Hybrid Petri net model of the fiss...

one of the most important and valuable goal of software development life cycle is software cost estimation or sce. during the recent years, sce has attracted the attention of researchers due to huge amount of software project requests. there have been proposed so many models using heuristic and meta-heuristic algorithms to do machine learning process for sce. cocomo81 is one of the most popular...

A hybrid particle swarm optimization (PSO) for multi-machine time scheduling problem (MTSP) with multicycles is proposed in this paper to choose the best starting time for each machine in each cycle under pre-described time window and a set of precedence machines for each machine; to minimize the total penalty cost. We developed hybrid algorithm by using a combination between PSO and Genetic Al...

Due to the complex nature of hybrid electric vehicles, control strategies based on engineering intuition frequently fail to achieve satisfactory overall system efficiency. This paper presents a procedure for improving the energy management strategy for a parallel hybrid electric truck on the basis of dynamic optimization over a given drive cycle. Dynamic Programming techniques are utilized to d...

In this study, a hybrid approach based on seasonal decomposition (SD) and least squares support vector regression (LSSVR) model is proposed for air passenger forecasting. In the formulation of the proposed hybrid approach, the air passenger time series are first decomposed into three components: trend-cycle component, seasonal factor and irregular component. Then the LSSVR model is used to pred...

Bio-inspired V2O5–polymer hybrid films were prepared following a one-step self-organization procedure based on liquid crystal formation of organic and inorganic components. These materials were previously reported to exhibit advantageous mechanical properties, comparable to biomaterials, such as human bone and dentin. Here, we show that these hybrid films prepared via a fast and simple synthesi...

This paper presents a technique for clock multiplication without local oscillators. This technique uses a DLL, thus presenting lower jitter than traditional PLL-based oscillator systems. Furthermore, it provides directly 50% duty-cycle clocks. This method is implemented both in a programmable custom circuit able to perform clock multiplication with integer factors from 2 to 8, and in a simpler ...

We address how feedback to a bursting biological pacemaker with intrinsic variability in cycle length can affect that variability. Specifically, we examine a hybrid circuit constructed of an isolated crab anterior burster (AB)/pyloric dilator (PD) pyloric pacemaker receiving virtual feedback via dynamic clamp. This virtual feedback generates artificial synaptic input to PD with timing determine...