Dental Pulp Stem Cells (DPSCs) can be found within the cell rich zone of dental pulp. These stem cells, under specific stimuli, differentiate into many cell types which have wide therapeutic applications.   The dental stem cells are derived from both deciduous and permanent teeth. The viable dental stem cells are very simple to collect, without any mortality and morbidity. Dental pulp stem c...

introduction based on previous researches, dental pulp stem cells (dpscs) are easily accessible with limited morbidity after collection. their embryonic origin, from neural crests, explains their multipotency. dpscs are primarily derived from the pulp tissues of the teeth.objective: this study was undertaken to isolate, culture, and characterize two different third molar and first premolar huma...

objective: by date investigations have indicated the presence of stem cells within the pulp tissue of both temporary and permanent human teeth. in the present study, these stem cells were compared in terms of their growth kinetics and culture requirements. materials and methods: stem cells within the pulp of the human third molar (permanent tooth) and the deciduous incisor (temporary tooth) wer...

background: it is still controversial that the stem cells isolated from human dental pulp meets the criteria for mesenchymal stem cells (mscs). the aim of the present study was to examine whether or not they are mscs, or are distinct stem cells population residing in tooth pulp.   methods: adherent fibroblastic cells in the culture of pulp tissue from human third molars were propagated through ...

Trisomy 21, the commonest constitutional aneuploidy in humans, causes profound perturbation of stem and progenitor cell growth, which is both cell context dependent and developmental stage specific and mediated by complex genetic mechanisms beyond increased Hsa21 gene dosage. While proliferation of fetal hematopoietic and testicular stem/progenitors is increased and may underlie increased susce...

Fertility preservation strategies are currently being developed for boys facing spermatogonial stem cell (SSC) loss. However, it is not clear yet which transplantation strategy would be the best choice. Therefore, the aim of the work presented in this thesis was both to compare these strategies and to study how to improve their efficiency. The efficiency to restore spermatogenesis after transpl...

background: in this study, we examined a new two step induction protocol for improving the differentiation of human umbilical cord blood-derived mesenchymal stem cells into neural progenitor cells. materials and methods: human umbilical cord blood-derived mesenchymal stem cells were first cultured in dulbecco’s modified eagle medium supplemented with 10% fetal bovine serum in a humidified incub...