objective: common variable immunodeficiency (cvid) is one of the most frequent cases of primary immunodeficiency. it is likely that this heterogeneous disease is caused by several distinct genetic disorders. the activation-induced cytidine deaminase (aid) enzyme is involved in class switching, somatic hypermutation (shm) and processes associated with gene conversion in the germinal center. in o...

hepatitis b surface antigen is the first genetically engineered vaccine licensed for human use. various strategies have been proposed to obtain a vaccine that would bypass the need for injection. in this study, a non-toxic portion of heat-stable enterotoxin of escherichia coli that is capable of adhering to epithelial cells was inserted at amino acid position 112 of hepatitis surface antigen. t...

The production of interferon (IFN) was investigated in human peripheral lymphocyte cultures stimulated by mumps virus. IFN-alpha and IFN-gamma were produced in lymphocyte cultures from immune donors. However, no IFN-gamma was produced in lymphocyte cultures from nonimmune donors. IFN-alpha was produced by B lymphocytes, and IFN-gamma was produced by T lymphocytes. An increase in the production ...

unresponsiveness to hepatitis b surface antigen (hbsag) has been shown to be associated with dysfunction of the presenting cells (apc) and defect in the specific b-lymphocyte and/or t-lymphocyte repertoires.   direct determination of the frequency of specific t-lymphocytes together with complementary analysis of the naive circulating immune cells could provide valuable information about the cel...

Cell membrane-derived nanoparticles are becoming more attractive because of their ability to mimic many features of their source cells. This study reports on a biomimetic delivery platform based on human cytotoxic T-lymphocyte membranes. In this system, the surface of poly-lactic-co-glycolic acid nanoparticles was camouflaged using T-lymphocyte membranes, and local low-dose irradiation (LDI) wa...

background: genistein (gen), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer. objective: the potential immunomodulatory effects of genistein on the immune system and against tc-1 tumor cell line were evaluated in adult female c57bl/6 mice. methods: mice were treated with gen 10 days before to 10 days after the tumor indu...

The cytotoxicity of a resin-based material can be evaluated on isolated human lymphocyte. Since resin-based dental materials have been used with increasing frequency in anterior and posterior teeth restorations, the uncured resin monomers are leached out from the restorations and diffuses into the dentine and ultimately hampers the odontoblastic layers of pulp as well as gingiva. It is also rea...

4. Kikutani H, Inui S, Sato R, Barsumian E, Owaki H, Yamasaki Y, Kaisho T, Uchibayashi N, Hardy R, Hirano T, Tsunasawa 5, Sakiyama F, Svemura M, Kishimoto T: Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell 47:657, 1986 5. Ikuta K, Takami M, Kim CW, Honjo T, Miyoshi T, Tagaya Y, Kawabe T, Yodoi J: Human Lymphocyte Fc receptor for IgE: Sequence homology of its cloned c...

Thirteen adherent human non-lymphocyte cell lines were tested for their susceptibility to infection by human immunodeficiency virus. Productive infection could be demonstrated in three of five colorectal carcinoma cell lines examined; the other eight human non-lymphocyte cell lines were uninfectible. A susceptible colon carcinoma cell line (HT29), as well as normal colonic mucosa, was shown to ...