Control of the expression of the human insulin-like growth factor II gene is known to be complex, displaying both tissue-specific and developmental regulation. Insulin-like growth factor II is expressed at high levels in most tissues in the human fetus and appears to be important in fetal growth. In adult life, high levels of expression are found chiefly in liver, kidney, skin, nerve, and muscl...

In fibroblasts in culture, the levels of cyclin Dl niRN \ are growth regulated. In mouse and in human fibroblasts, both serum and plateletderived growth factor increase cyclin Dl mRNA levels with similar kinetics of induction. Insulin-like growth factor 1 by itself does not induce cyclin Dl expression, and an antisense oligodeoxynucleotide to the insulin-like growth factor 1 receptor RNA does n...

In fibroblasts in culture, the levels of cyclin Dl niRN \ are growth regulated. In mouse and in human fibroblasts, both serum and plateletderived growth factor increase cyclin Dl mRNA levels with similar kinetics of induction. Insulin-like growth factor 1 by itself does not induce cyclin Dl expression, and an antisense oligodeoxynucleotide to the insulin-like growth factor 1 receptor RNA does n...

Using complementary DNAs of human insulin-like growth factors as probes, expressions of the insulin-like growth factors I and II mRNA were examined in seven human hepatoma tissues and their adjacent nontumorous livers. The level of insulin-like growth factor I mRNA in hepatoma was lower than that in the nontumorous liver control. This phenomenon was probably caused by the low expression of huma...