conclusions our results revealed the possible crucial genes and mirnas involved in the initiation and progression of hcc cells infected with hcv. results based on the topological analysis of mirna-hubgene network, we identified the key hub mirnas. in order to identify the most important common sub-network, we aligned two ppi networks using netal tool. the c-jun gene was identified as the most i...

Numerous recently uncovered cartels operated along the supply chain, with firms at one end facilitating collusion other – hub-and-spoke arrangements. These are hard to rationalize because they induce double marginalization and higher costs. We examine Canada’s alleged bread cartel provide first comprehensive analysis of collusion. make three contributions: i) Using court documents pricing data ...

In this paper, we consider the design of large-scale multiple allocation hub-and-spoke transportation networks in a competitive environment. We adopt a generic hub arc location model that locates arcs with discounted transport costs connecting pairs of hub facilities. Two firms compete for customers in a Stackelberg framework where the leader firm locates hub arcs to maximize its revenue, given...

The hierarchical hub location problem is encountered three-level network that is applied in production-distribution system, education system, emergency medical services, telecommunication network, etc. This paper addresses the hierarchical hub covering problem with single assignment accounting for mandatory dispersion of central hubs restriction as a special case. This formulation with incorpor...

This paper develops an air passenger model that deals with city-pair demand generation and demand assignment in a single framework. Using publicly available and regularly collected panel data, the model captures both time series and cross-sectional variation of air travel demand. The empirical analysis finds that pattern of correlations among alternatives can be described by a three-level neste...

In this paper, we introduce the new paradigm used in the most recent ARPA-sponsored Continuous Speech Recognition (CSR) evaluation and then discuss the important features of the test design. The 1993 CSR evaluation was organized in a novel fashion in an attempt to accomodate research over a broad variety of important problems in CSR while maintaining a clear program-wide research focus. Further...

In this paper, we consider the design of large-scale hub-and-spoke transportation networks in a competitive environment. We adopt the hub arc location model that locates arcs with discounted transport costs connecting pairs of hub facilities. Two firms compete for passengers in a Stackelberg framework where the leader firm locates hub arcs to maximize its revenue, given that the follower firm w...

A new hub-and-spoke (H&S) model for restructuring the traditional biological science curriculum is presented here. The H&S emphasises integration of sub-disciplines biology and with other scientific disciplines. In this model, undergraduate courses that include both theory a stand-alone laboratory component are replaced discovery-based research act as hub, servicing discipline-specific ...