OBJECTIVE To evaluate the feasibility of conducting a large randomized trial of HRT in symptomatic women with early-stage breast cancer. DESIGN Open randomized study. SETTING Outpatient clinics at The Royal Marsden and St. George's Hospitals, London. PATIENT(S) One hundred postmenopausal women with early-stage breast cancer, experiencing vasomotor symptoms and/or vaginal dryness. INTERV...

In the 1990s, two randomised clinical trials started in Scandinavia addressing whether hormone replacement therapy (HRT) is safe for women with previous breast cancer. We report the findings of the safety analysis in HABITS (hormonal replacement therapy after breast cancer—is it safe?), an open randomised clinical trial with allocation to either HRT or best treatment without hormones. The main ...

OBJECTIVE To describe changes in prescription of hormone replacement therapy (HRT) in Asturias (Spain) after the publication of the results of the Women's Health Initiative and the Million Women Study and following the recommendations of the Spanish Drugs Agency to women and prescribers (2004-2005). METHODS We performed a quasiexperimental study with no control group. The data used consisted ...

Journal of Family Planning and Reproductive Health Care 2004: 30(1) Introduction “I’m confused, anxious, wary. The press coverage on hormone replacement therapy (HRT) has left me feeling concerned and, frankly, troubled. Is HRT a good thing or isn’t it? Should I be taking it or shouldn’t I? I’ve even become doubtful about taking medical advice on all this. To be frank, I’m going to gather infor...

CONTEXT Previous studies have shown a sex-specific increased risk of Alzheimer disease (AD) in women older than 80 years. Basic neuroscience findings suggest that hormone replacement therapy (HRT) could reduce a woman's risk of AD. Epidemiologic findings on AD and HRT are mixed. OBJECTIVE To examine the relationship between use of HRT and risk of AD among elderly women. DESIGN, SETTING, AND...

PURPOSE Molecular and clinical observations suggest a role of sex steroid hormones in the occurrence of meningioma. However, there is limited and often conflicting data on the use of hormone replacement therapy (HRT) as a possible risk factor for meningioma. The goal of this study was to investigate whether there is an association between a diagnosis of meningioma and either current or past HRT...

Prior to the unexpected early termination of the Women's Health Initiative (WHI) trial of continuous conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA), the prevailing view was that hormone replacement therapy (HRT) was a low-risk intervention with immediate value for symptom relief in recently menopausal women, and that it probably conferred long-term protection against th...

BACKGROUND This study compared the efficacy of transdermally administered estradiol with that of orally administered conjugated equine estrogens (CEE) on the renin-angiotensin system, plasma bradykinin level, and blood pressure (BP) in normotensive postmenopausal women (PMW). METHODS A total of 38 normotensive PMW were randomly assigned to two groups. The transdermal hormone replacement thera...

STUDY OBJECTIVES To compare the demographic, behavioural, and biological correlates of use of hormone replacement therapy (HRT) in women with an intact uterus and women who have undergone hysterectomy. DESIGN Cross sectional analysis of data from the Busselton Health Study and the 1994 Healthway-National Heart Foundation Risk Factor Survey. SETTING Busselton and Perth, Western Australia, 19...

BACKGROUND Studies have documented elevated levels of liver enzymes in many females with Turner syndrome (TS). Histology has shown a range of changes. Treatment with female hormone replacement therapy (HRT) reduces liver enzymes. AIM To study quantitative liver functions in TS in detail with and without HRT. DESIGN Randomized crossover study with active treatment (HRT in TS and P-pill in co...