BACKGROUND Prospective studies suggested an association between pioglitazone (Actos) use and the development of bladder cancer. Cancer pathology among pioglitazone users has not been characterized. We chose to compare the surgical pathology among diabetic users and non-users, as well as non-diabetic patients who underwent radical cystectomy for bladder cancer. METHODS Our single-center, prosp...

OBJECTIVE Regional recurrence is common following surgery for T1/T2 oral tongue squamous cell carcinoma (SCC). Tumor depth >4.0 mm is commonly assigned as an indication for prophylactic neck dissection to improve regional control. Prophylactic neck dissection may detect extracapsular extension, a poor prognostic sign where adjuvant chemotherapy is indicated. The hypothesis in this study is that...

This paper proposes a method for local deformation analysis of the heart's left ventricle (LV) which is of an utmost interest in characterizing the myocardium disease extent and severity. Our method is based on regional curvature variation calculation using the Hotelling T2 two samples difference metric. Our approach is validated on real data obtained from myocardial scintigraphy imaging techni...