The neutral mutation rate is known to vary widely along human chromosomes, leading to mutational hot and cold regions. We provide evidence that categories of functionally related genes reside preferentially in mutationally hot or cold regions, the size of which we have measured. Genes in hot regions are biased toward extracellular communication (surface receptors, cell adhesion, immune response...

Background: The role of temperature changes, as an environmental risk factor, in the human health status has been investigated in recent studies. Accordingly, the present two-year study was conducted to evaluate the incidence of myocardial infarction (MI) in warm and cold seasons in Ali-ibn Abi Talib Hospital, Rafsanjan, Iran. Materials and Methods: In this descriptive and cross-sectional st...

BACKGROUND Many studies have reported associations between temperature extremes and cardiovascular mortality but little has been understood about differences in the effects on acute and chronic diseases. The present study examines hot and cold spell effects on ischaemic heart disease (IHD) mortality in the Czech Republic during 1994-2009, with emphasis upon differences in the effects on acute m...

BACKGROUND Little evidence is available about the association between temperature and cerebrovascular mortality in China. This study aims to examine the effects of ambient temperature on cerebrovascular mortality in different climatic zones in China. METHOD We obtained daily data on weather conditions, air pollution and cerebrovascular deaths from five cities (Beijing, Tianjin, Shanghai, Wuha...

PURPOSE To examine seasonal variations in urinary symptoms in Korean men with lower urinary tract symptoms and benign prostatic hyperplasia (LUTS/BPH). MATERIALS AND METHODS Records were obtained from a consecutive database of LUTS/BPH patients from March 2010 to February 2014. A total of 1,185 patients were suitable for analysis. The International Prostate Symptom Score (IPSS), uroflowmetric...

The Friedman equation is solved for a universe containing hot-dark matter and cold dark matter. In this scenario, hot-dark matter drives an accelerating universe no cold dark matter.

Objective. To illustrate the difference in cold/hot natural properties and therapeutic effect of coptis-evodia herb couples by using cold/hot plate differentiating technology and microcalorimetry combined with material basis analysis in vivo and in vitro. It showed that animal retention ratio in hot pad significantly decreased along with the decrease in coptis proportion in coptis-evodia herb c...

in this paper, to address the effect of reactor performance and configuration of biodiesel production on subsequent process parameters (including mass & energy consumption, required facilities etc.) two diverse biodiesel production processes (from plant oil) were implemented/designed using aspen hysys v7.2. two series reactors were taken into account in these designs where in the first and seco...

The most important reason mentioned for the early discontinuation of breast feeding and introduction of supplementary bottles is Perceived Insufficient Milk (PIM), which is relatively common in women. This is of public health concern because the use of breast milk substitutes increases the risk of morbidity and mortality among infants in developing countries and shortens birth intervals. Thus, ...

introduction: traditional iranian medicine (tim) is accompanied by little side effects in experience. the mechanisms involved in tim are not much clear. the purpose of this study is assessment of differences of warm and cold nature persons in neuroendocrine system and cytokine pattern (th1/th2) of immune responses. methods: thirty seven 20 to 40 years old male volunteers were divided into 2 gro...