Pathogen infection often leads to the expression of virulence and host death when the host-pathogen symbiosis seems more beneficial for the pathogen. Previously proposed explanations have focused on the pathogen's side. In this work, we tested a hypothesis focused on the host strategy. If a member of a host population dies immediately upon infection aborting pathogen reproduction, it can protec...

Five levels of disease expression were scored in a cross-inoculation study of 120 host and 60 pathogen lines of wild flax Linum marginale and its rust fungus Melampsora lini sampled from six natural populations. Patterns of partial resistance showed clear evidence of gene-for-gene interactions, with particular levels of partial resistance occurring in specific host-pathogen combinations. Sympat...

The threat posed to human health by arthropod-borne bacteria is most vividly demonstrated by the devastating epidemics caused by the plague. The diversity of pathogenic bacteria spread by arthropods is probably underestimated. Recently recognized infectious diseases such as Lyme disease and ehrlichiosis are caused by bacteria transmitted by arthropods. Bacteria which alternate between arthropod...

In the context of host-pathogen interaction, host cell receptors and signaling pathways are essential for both invading pathogens, which exploit them for their own profit, and the defending organism, which activates early mechanism of defense, known as innate immunity, to block the aggression. Because of their central role as scaffolding proteins downstream of activated receptors, β-arrestins a...

Phytophthora cinnamomi is among the most destructive plant pathogens that affect many host plants in different ecosystems. Economically important hosts of this pathogen include avocado (Persea americana), and oomycete may cause large-scale epidemics. This study analyzed potential geographic distribution P. (pathogen) (host), relation to multiple Americas. Niche overlap between were also evaluat...

The dynamics of directly transmitted pathogens in natural populations are likely to result from the combined effects host traits, pathogen biology, and interactions among within a host. Discovering how these factors work concert shape variation host–multi-pathogen systems is fundamental understanding population health. Here, we describe temporal incidence then elucidate effect hosts trait, seas...

My presentation will focus on host-cell pathogen interactions in tuberculosis. However, I would first like offer a brief introduction to the tuberculosis disease. I believe it is important to remember that merely an estimated 5-10% of individuals exposed or infected with the Mycobacterium tuberculosis bacteria actually develop tuberculosis. In other words, the human population, as a whole, is e...