1 2 3 4 5 6 7 8 Quantitative and Functional Interrogation of Parent-of-Origin 9 Allelic Expression Biases in the Brain 10 11 Julio D. Perez, Nimrod D. Rubinstein, Daniel E. Fernandez, Stephen W. Santoro, 12 Leigh A. Needleman, Olivia Ho-Shing, John J Choi, Mariela Zirlinger, Shau-Kwaun 13 Chen, Jun S. Liu, Catherine Dulac* 14 Department of Molecular and Cellular Biology, Harvard University, How...

We present a holmium-doped all-fiber master oscillator power amplifier (MOPA) system operating at 2108 nm targeting optical frequency conversion applications. The MOPA delivers pulses of 0.52 mJ energy 10 kHz repetition rate after three amplification stages, with close to square-shaped temporal profile 50 ns duration, diffraction-limited beam quality and linear polarization. Challenges achievin...

OBJECTIVES The aim of this study was to assess the safety and effectiveness of ureteroscopy and Holmium: Yttrium-Aluminum-Garnet lithotripsy for the treatment of ureteral stones with different localizations in symptomatic pregnant women. METHODS A retrospective analysis was performed on 19 pregnant patients referred to our center between January 2005 and December 2012 with symptomatic hydrone...

OBJECTIVE The aim of this study is to compare Holmium laser enucleation of the prostate with another minimally invasive technique, the laparoscopic simple prostatectomy. MATERIALS AND METHODS We compared outcomes of a series of 40 patients who underwent laparoscopic simple prostatectomy (n=20) with laser enucleation of the prostate (n=20) for large adenomas (>100 grams) at our institution. St...

BACKGROUND AND OBJECTIVES Advances in endoscopic techniques have transformed the management of urolithiasis. We sought to evaluate the role of such urological interventions for the treatment of complex biliary calculi. METHODS We conducted a retrospective review of all patients (n=9) undergoing percutaneous holmium laser lithotripsy for complicated biliary calculi over a 4-year period (12/200...

PURPOSE To evaluate the clinical efficacy of flexible ureteroscope (F-URS) combined with holmium laser lithotripter in treating renal calculi in horseshoe kidney. MATERIALS AND METHODS From November 2010 to December 2013, the medical history and charts of sixteen patients (mean age 42.9 ± 11.6 years, range 26-66 years), including 13 males and 3 females were analyzed retrospectively. Mean ston...

introduction: to assessment of the efficacy and safety of transurethral cystolithotripsy of large bladder stones by holmium laser in the outpatient setting. methods: in a prospective study, 48 consecutive adult patients with large bladder stones, were enrolled for transurethral cystolithotripsy. patients older than 18 years, with bladder stones larger than 2 cm were enrolled. urethral stricture...

OBJECTIVES To compare the safety and cost-effectiveness of ureterorenoscopic holmium:yttrium-aluminum-garnet (YAG) laser lithotripsy (URSL) with extracorporeal shock wave lithotripsy (ESWL) for proximal ureteral stones. METHODS This investigation assessed 220 patients with upper ureteral stones. Those in the ESWL group were treated on an outpatient basis using the Medispec Econolith 2000 (Med...

introduction: surgical management of pediatric urinary calculi evolved dramatically over the past two decades. however, with the miniaturization of equipment and with improvisation of endourologic techniques, access to the entire pediatric urinary system is possible. ho: yag laser provides more maneuverability during transuretereal lithotripsy (tul) than the pneumatic system which uses a metal ...

Micelles derived from poly(ε-caprolactone) (PCL) poly(ethylene glycol)(PEG) diblock copolymers (HO-PCLn-b-PEG32-RX, R = -O(CH2)3S(CH2)2-; X = -CO2(-), -SO3(-), -NH3(+)) show corona charge selective degradation catalyzed by P. cepacia lipase isoforms.