نتایج جستجو برای: hla dq b1

تعداد نتایج: 61570  

Journal: :Blood 2004
Neal Flomenberg Lee Ann Baxter-Lowe Dennis Confer Marcelo Fernandez-Vina Alexandra Filipovich Mary Horowitz Carolyn Hurley Craig Kollman Claudio Anasetti Harriet Noreen Ann Begovich William Hildebrand Effie Petersdorf Barbara Schmeckpeper Michelle Setterholm Elizabeth Trachtenberg Thomas Williams Edmond Yunis Daniel Weisdorf

Outcome of unrelated donor marrow transplantation is influenced by donor-recipient matching for HLA. Prior studies assessing the effects of mismatches at specific HLA loci have yielded conflicting results. The importance of high-resolution matching for all HLA loci has also not been established. We therefore examined the effects of HLA matching (low or high resolution or both) on engraftment, g...

Journal: :The Journal of clinical investigation 1997
J Endl H Otto G Jung B Dreisbusch F Donie P Stahl R Elbracht G Schmitz E Meinl M Hummel A G Ziegler R Wank D J Schendel

Glutamic acid decarboxylase (GAD) has been defined as a major target antigen in insulin-dependent diabetes mellitus (IDDM). To identify the molecular ligands triggering a T cell response to GAD, a panel of human GAD65-specific T lymphocyte lines was generated from peripheral blood of three recent onset IDDM patients. All lines derived from a patient expressing the high-risk-conferring HLA-DR*03...

Journal: :Journal of Immunology 2023

Abstract Sensitization to nickel (Ni2+) is the most common T cell mediated type IV hypersensitivity, although mechanisms by which Ni2+ alters antigen presentation are not understood. To study how TCR then recognizes bound MHC molecule, we performed paired single RNA sequencing of PBMCs from two highly sensitized subjects orthopedic implants and characterized three specific CD4+ clones. One rest...

Journal: :Transplantation 2014
Anat R Tambur Jimmy Rosati Shirley Roitberg Denis Glotz John J Friedewald Joseph R Leventhal

BACKGROUND Human leukocyte antigen (HLA)-DQ has emerged as the alloantibody most frequently associated with the generation of de novo donor-specific antibody (DSA), antibody-mediated-rejection, and unfavorable transplantation outcome. METHODS The generation of HLA-DQ de novo DSA was interrogated in 40 transplant recipients who were immunologically naive before their failed transplantation. Ep...

Journal: :Respiratory Research 2005
Massimo Amicosante Floriana Berretta Milton Rossman Richard H Butler Paola Rogliani Ella van den Berg-Loonen Cesare Saltini

BACKGROUND Susceptibility to beryllium (Be)-hypersensitivity (BH) has been associated with HLA-DP alleles carrying a glutamate at position 69 of the HLA-DP beta-chain (HLA-DPGlu69) and with several HLA-DP, -DQ and -DR alleles and polymorphisms. However, no genetic associations have been found between BH affected subjects not carrying the HLA-DPGlu69 susceptibility marker. METHODS In this repo...

2013
Ingeborg Deschamps Min Sik Park Laurent Degos Francis Galibert

Family and population studies indicate that predisposition to insulin-dependent (type I) diabetes mellitus (IDDM) is polygenic. It has been shown that the absence of the aspartic acid in position 57 (Asp57) of the DQ/i chain is positively correlated to IDDM. However, Asp57-negative haplotypes do not always confer susceptibility and conversely, some Asp57-positive haplotypes seem to be disease a...

Journal: :Journal of immunology 2001
T Matsuoka H Tabata S Matsushita

When HLA-DR, -DQ, and -DP were cross-linked by solid-phase mAbs, monocytes produced monokines and only anti-DR markedly activated mitogen-activated protein (MAP) kinase extracellular signal-related kinase, whereas anti-DR, anti-DQ, and anti-DP all activated MAP kinase p38. Activation of extracellular signal-related kinase was not inhibited by neutralizing Ab to TNF-alpha. Anti-DR and DR-restric...

ژورنال: ابن سینا 2011
امیر زرگر, علی اکبر , جباری, حسین , حیدرنیا, حسن , رسولی نژاد, مهرناز , محرز, مینو , مرادمند بدیع , بنفشه ,

مقدمه: HLA کلاس Iو IIنقش عمده‌ای در پاسخ ایمنی میزبان نسبت به ویروس نقص ایمنی انسانی (HIV) دارد بطوری که به عنوان یک عامل مهم در پیشرفت به سمت بیماری ایدز شناخته می‌شود. هدف مطالعه بررسی ارتباط انواع آلل‌های HLAمستعد کننده و پیشگیری کننده با سیر بیماری در افراد HIV مثبت در مقایسه با افراد سالم می‌باشد. روش بررسی: این بررسی بصورت مورد– شاهدی انجام شد، که HLA کلاس I (HLA-A-B) و کلاس II (HLA-D...

2005
BREMINAND MAHARAJ

To determine whether genetic factors could be involved in the pathogenesis of rheumatic heart disease, we performed HLA-A and HLA-B typing in 120 black patients with severe chronic rheumatic heart disease requiring cardiac surgery, and HLA-DR and HLA-DQ typing in 103 and 97 of these patients, respectively. The HLA typing was done by a standard microlymphocytotoxicity method. Patients were 12 to...

Ali Akbar Amirzargar, Hossein Mortazavi Maede Rayati Damavandi Maryam Daneshpazhoooh Nafiseh Esmaili Sheyda Chams-Davatchi Zeinab Aryanian

Background: A common Human Leukocyte Antigen (HLA) class II allele, DQβ1*03:01, seems to be associated with Bullous pemphigoid (BP) in Caucasians whereas previous studies in other ethnic groups showed other HLA class II alleles as genetic predisposing factors for BP. Objective: To investigate the association of HLA class II alleles and haplotypes with BP in Iranian population. Methods: Fifty pa...

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