نتایج جستجو برای: hiv i
تعداد نتایج: 1238862 فیلتر نتایج به سال:
The development of an HIV vaccine poses an unprecedented challenge to the scientific community. The inexorable spread of HIV worldwide and the devastating clinical consequences of AIDS can only be contained by an effective vaccine. Yet, almost two decades after the first demonstration of HIV and its etiologic role in AIDS, this vaccine still is a goal, not a reality. In this Perspective, I cons...
This work is conducted to investigate how the initial concentration and the severity of HIV which spreads over the lymphoid tissues affect the dynamics of infection, and to what extent?. Therefore, we vary the initial concentration of HIV infected cells, DC M P _ , and the severity of HIV infected cells, 4 _ T I P , of a stochastic cellular automaton for HIV infection which describes the dynami...
OBJECTIVE--To characterise the natural history of sexually transmitted HIV-I infection in homosexual and bisexual men. DESIGN--Cohort study. SETTING--San Francisco municipal sexually transmitted disease clinic. PATIENTS--Cohort included 6705 homosexual and bisexual men originally recruited from 1978 to 1980 for studies of sexually transmitted hepatitis B. This analysis is of 489 cohort members ...
مقدمه: hla کلاس iو iiنقش عمده ای در پاسخ ایمنی میزبان نسبت به ویروس نقص ایمنی انسانی (hiv) دارد بطوری که به عنوان یک عامل مهم در پیشرفت به سمت بیماری ایدز شناخته می شود. هدف مطالعه بررسی ارتباط انواع آلل های hlaمستعد کننده و پیشگیری کننده با سیر بیماری در افراد hiv مثبت در مقایسه با افراد سالم می باشد. روش بررسی: این بررسی بصورت مورد– شاهدی انجام شد، که hla کلاس i (hla-a-b) و کلاس ii (hla-dr, d...
BACKGROUND The challenges of identifying acute HIV infection (AHI) have resulted in a lack of critical information on early AHI that constrains the development of therapeutics that are designed to eradicate HIV from the infected host. METHODS AHI participants were recruited from the Thai Red Cross Anonymous Clinic in Bangkok, Thailand into the RV254/SEARCH010 protocol and categorised accordin...
مقدمه:HIV یکی از گسترده ترین اپیدمی ها در جهان در حال حاضر می باشد. تقریباً تمام موارد آلودگی به HIV ناشی از رفتارهای پرخطر مثل سوء مصرف مواد و رفتارهای پرخطر جنسی می باشد و ویژگیهای شخصیتی نقش مهمی در این مورد بازی می کنند. درک ویژگیهای شخصیتی افراد آلوده به HIV می تواند در برنامه های پیشگیرانه HIV و همچنین اداره و درمان این بیماران مفید باشد. این مطالعه ابعاد شخصیتی افراد وابسته به مواد آلوده ...
Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. We utilized a liquid chromato...
Immunoelectron microscopy was applied to study the antigenic make-up of human and simian immunodeficiency viruses (HIV, SIV) grown in cells expressing either MHC class I (Molt-3) or MHC class I and II (H9) antigens. A variety of antibodies directed against the surface glycoprotein gp120 of HIV and against MHC class I and II antigens were employed. Consistent with earlier observations on the los...
Because endogenous interferon type I (IFN-I) produced by HIV-1 infection might complicate the analysis of therapeutically administered IFN-I, we tested different humanized mouse models for induction of IFN-I during HIV-1 infection. While HIV-1 induced high levels of IFN-α in BLT mice, IFN-I was undetectable following infection in the Hu-PBL mouse model, in which only T cells expand. We therefor...
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