Seven cases are presented in which enlargement of the pituitary stalk was demonstrated by computed tomography (CT). Histiocytosis X, sarcoidosis, and metastatic cancer were the proven or presumed causes. The discovery of pituitary stalk enlargement prompted radiation treatment in three patients and led to the diagnosis of previously unsuspected diabetes insipidus in one.

Adult histiocytosis X involving the CNS caused progressive spastic paraparesis. The diagnosis was made by immunoreactive anti-S100 protein antibody staining and from the presence of Birbeck granules in biopsy specimens of skin lesions. Neuropathological examination showed massive proliferation and infiltration of S-100 containing histiocyte-like cells and reactive astrocytes throughout the CNS.

BACKGROUND Langerhans cell histiocytosis affects mainly young children and features an accumulation of CD1a+ dendritic Langerhans cells in the bone, skin, and other organs. A few cases of Langerhans cell histiocytosis on the penis have been reported in the literature. We present a case of Langerhans cell histiocytosis on the penis and review the similar cases in the literature. CASE PRESENTAT...

STATEMENT OF THE PROBLEM Langerhans cell histiocytosis is a rare disease with unknown pathogenesis and is characterized by local or disseminated proliferation of Langerhans cells. There is no previous investigation on prevalence of oral Langerhans cell histiocytosis in Iranian population. PURPOSE The purpose of this study was to assess the relative frequency of oral Langerhans cell histiocyto...

Address correspondence to: Dr. Arunkumar Krishnan, C-137, Karthikeyan salai, Periyar Nagar, Perambur, Chennai-600083, Tamilnadu, India; E-mail: [email protected] Langerhans cell histiocytosis (LCH), previously known as histiocytosis X, encompasses a diverse group of proliferative disorders characterized by infiltration and accumulation of histiocytes and other immune effector cells w...